General
Preferred name
palonosetron
Synonyms
RS-25259-197 ()
Palonosetron HCl ()
RS 25259 ()
PALONOSETRON HYDROCHLORIDE ()
Palonosetron (Hydrochloride) ()
RS25259, RS 25259 197 ()
RS 25259, RS 25259 197 ()
Posfrea ()
Palonocetron hydrochloride ()
Palonosetron hospira ()
Aloxi ()
Palonosetron hydrochloride component of akynzeo ()
Palonosetron accord ()
Palonosetron (as hydrochloride) ()
Palonosetron, (3as, 3s)- ()
(-)-palonosetron ()
NSC-743769 ()
Palonosetron-d3 (hydrochloride) ()
P&D ID
PD013065
CAS
135729-62-3
135729-56-5
1021481-16-2
135729-61-2
Tags
available
drug
Approved by
FDA
PMDA
EMA
First approval
2003
Drug indication
Nausea
post operative nausea and vomiting
Neoplasm
Drug Status
approved
investigational
Max Phase
4.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Palonosetron hydrochloride is a 5-HT3 antagonist primarily used to prevent acute, delayed, and overall chemotherapy-induced nausea and vomiting. In addition, Palonosetron hydrochloride exhibits moderate anti-flavivirus activity and potent anti-Zika virus activity in mammalian cells. Palonosetron hydrochloride also possesses antidepressant activity[1][2][3][4].
PRICE
29
DESCRIPTION
Palonosetron is a 'serton' family drug, that is a serotonin 5-HT3 antagonist. Most setrons are antiemetics, apart from and , which are irritable bowel syndrome therapeutics. Setrons are the most widely prescribed antiemetic drugs used in the management of chemotherapy-induced nausea and vomiting (CINV).
(GtoPdb)
DESCRIPTION
Selective activator of SUR1 Kir6.2 channels
(Tocris Bioactive Compound Library)
DESCRIPTION
Palonosetron hydrochloride (RS 25259) is a 5-HT3 antagonist used in the prevention and treatment of chemotherapy-induced nausea and vomiting.
(TargetMol Bioactive Compound Library)
DESCRIPTION
Palonosetron is an antagonist of the serotonin (5-HT) receptor subtype 5-HT3. Palonosetron has been used in the treatment of postoperative or chemotherapy-induced nausea and vomiting.
(Enamine Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
34
Axon Medchem Screening Library
CeMM library of unique drugs (CLOUD)
ChEMBL Approved Drugs
ChEMBL Drugs
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
Enamine Bioactive Compounds
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
Guide to Pharmacology
LSP-MoA library (Laboratory of Systems Pharmacology)
Mcule NIBR MoA Box Subset
MedChem Express Bioactive Compound Library
NCATS Inxight Approved Drugs
NIH Clinical Collections (NCC)
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
Tocris Bioactive Compound Library
VGSC-DB
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
74
Molecular Weight
296.19
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
0
Rotatable Bonds
1
Ring Count
6
Aromatic Ring Count
1
cLogP
2.66
TPSA
23.55
Fraction CSP3
0.63
Chiral centers
2.0
Largest ring
6.0
QED
0.8
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Neuronal Signaling
GPCR/G protein
Anti-infection
Neuroscience
MOA
serotonin receptor antagonist
5-HT Receptor antagonist
Antagonist
5-HT3 Antagonists
Target
Serotonin 3a (5-HT3a) receptor
5-HT
5-HT Receptor
HTR3A
5-HT3 antagonist
Flavivirus
Primary Target
5-HT3 Receptors
Member status
member
Indication
nausea, vomiting
Therapeutic Class
Antiemetics
VGSC Target
Nav1.5
Source data
