General
Preferred name
EPZ020411
Synonyms
EPZ020411 HCl ()
P&D ID
PD013060
CAS
2070015-25-5
Tags
available
probe
Probe info
Probe type
calculated probe
Probe sources
Tool Compound Set
Probe targets
[[ compound.targets[t].gene_name ]]
Probe control
Probe control not defined
Orthogonal probes
3
No orthogonal probes found
Similar probes
1
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
EPZ020411 is a research tool compound which is a potent, and selective inhibitor of protein arginine methyltransferase 6 (PRMT6) .
(GtoPdb)
DESCRIPTION
EPZ020411 hydrochloride is a potent and selective small molecule PRMT6 inhibitor with an IC50 of 10 nM, and it displays >10-fold and 20-fold selectivity over PRMT1/8.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
4
BOC Sciences Bioactive Compounds
EUbOPEN Chemogenomics Library
Guide to Pharmacology
Tool Compound Set
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
13
Molecular Weight
442.29
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
2
Rotatable Bonds
12
Ring Count
4
Aromatic Ring Count
2
cLogP
3.47
TPSA
71.64
Fraction CSP3
0.64
Chiral centers
0.0
Largest ring
6.0
QED
0.52
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Protein arginine N-methyltransferase 6
Recommended Cell Concentration
None
Source data
