General
Preferred name
WHI-P97
Synonyms
KIN001-055 ()
WHI-P97, AC1L1GQE ()
WHI-P97 HCl ()
P&D ID
PD013031
CAS
211555-05-4
Tags
available
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE
66
PRICE
116
DESCRIPTION
WHI-P97 is a potent, cell-permeable and specific inhibitor of JAK3 (IC50 = 11 μM). It inhibits JAK3 in immune complex kinase assays in a dose-dependent fashion and reduces the invasiveness of EGFR positive human cancer cells in a dose-dependent manner.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
WHI-P97 is a potent and selective JAK-3 inhibitor, Ki= 0.6μM.
(Enamine Bioactive Compounds)
DESCRIPTION
WHI-P97 is a rationally designed potent inhibitor of JAK-3. IC50 value: Target: JAK3 Treatment of mast cells with WHI-P97 inhibited the translocation of 5-lipoxygenase (5-LO) from the nucleoplasm to the nuclear membrane and consequently 5-LO-dependent leukotriene (LT) synthesis after IgE receptor/FcepsilonRI crosslinking by >90% at low micromolar concentrations. WHI-P97 did not directly inhibit the enzymatic activity of 5-LO, but prevented its translocation to the nuclear membrane without affecting the requisite calcium signal.
(TargetMol Bioactive Compound Library)
DESCRIPTION
WHI-P97 HCl is a potent and selective JAK-3 inhibitor. WHI-P97 had an estimated Ki value of 0.09 microM from modeling studies and a measured IC50 value of 2.5 microM in EGFR kinase inhibition assays. WHI-P97 effectively inhibited the in vitro invasiveness of EGFR-positive human cancer cells in a concentration-dependent manner.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
1
Organisms
0
Compound Sets
10
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
CZ-OPENSCREEN Bioactive Library
Enamine Bioactive Compounds
EU-OPENSCREEN Bioactive Compound Library
LINCS compound set
MedChem Express Bioactive Compound Library
Selleckchem Bioactive Compound Library
Welcome Trust Cancer Drugs
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
21
Molecular Weight
452.93
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
2
Rotatable Bonds
4
Ring Count
3
Aromatic Ring Count
3
cLogP
4.62
TPSA
76.5
Fraction CSP3
0.12
Chiral centers
0.0
Largest ring
6.0
QED
0.56
QED
0.56
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
JAK3, MNK1
JAK3
JAK
Pathway
Angiogenesis/Chromatin/Epigenetic/Chromatin/Epigenetic/Stem Cells
Epigenetics
JAK/STAT Signaling
Protein Tyrosine Kinase/RTK
Stem Cell/Wnt
Angiogenesis
Chromatin/Epigenetic
Stem Cells
Tyrosine Kinase/Adaptors
Source data
