General
Preferred name
SITAXENTAN SODIUM
Synonyms
TBC11251 sodium salt ()
TBC11251 ()
Thelin ()
Sitaxsentan sodium ()
PF-1228305 ()
Sitaxsentan (sodium) ()
IPI 1040 (sodium) ()
TBC11251 (sodium) ()
TBC-11251 SODIUM ()
Sitaxsentan sodium salt ()
TBC-11251NA ()
TBC-11251Z ()
P&D ID
PD013027
CAS
210421-74-2
Tags
available
drug
Drug indication
Pulmonary hypertension
diastolic heart failure
Drug Status
approved
withdrawn
Max Phase
4.0
First approval
2006
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE
50
DESCRIPTION
Sitaxsentan is used for the treatment of pulmonary arterial hypertension. Sitaxentan is a competitive antagonist of endothelin-1 at the endothelin-A (ET-A) and endothelin-B (ET-B) receptors.
(Enamine Bioactive Compounds)
DESCRIPTION
Sitaxentan sodium inhibits ET-1-induced stimulation of phosphoinositide turnover with a Ki of 0.69 nM and a pA2 of 8.0.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
Sitaxsentan sodium (TBC11251 sodium salt) is a highly selective antagonist of endothelin A receptors.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
9
AdooQ Bioactive Compound Library
BOC Sciences Bioactive Compounds
ChEMBL Approved Drugs
ChEMBL Drugs
DrugMAP
Enamine Bioactive Compounds
EU-OPENSCREEN Bioactive Compound Library
MedChem Express Bioactive Compound Library
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
21
Molecular Weight
475.99
Hydrogen Bond Acceptors
8
Hydrogen Bond Donors
0
Rotatable Bonds
6
Ring Count
4
Aromatic Ring Count
3
cLogP
1.56
TPSA
109.8
Fraction CSP3
0.22
Chiral centers
0.0
Largest ring
6.0
QED
0.39
QED
0.39
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Endothelin Receptor
ET-A
Pathway
GPCR/G protein
Source data
