General
Preferred name
LDN-193189
Synonyms
DM 3189 ()
LDN-193189 2HCl ()
DM-3189 2HCl ()
LDN193189 Hydrochloride ()
LDN 193189 dihydrochloride ()
DM3189 ()
LDN 193189 ()
LDN193189 ()
LDN193189 HCl ()
LDN 193189 hydrochloride ()
LDN193189 (Tetrahydrochloride) ()
LDN193189 (dihydrochloride) ()
LDN193189 (hydrochloride) ()
LDN-193189 HCl ()
DM-3189 (Tetrahydrochloride) ()
DM-3189 (dihydrochloride) ()
DM-3189 (hydrochloride) ()
DM-3189 ()
LDN193189 ()
LDN-193189 (hydrochloride) ()
P&D ID
PD013013
CAS
1435934-00-1
1062368-24-4
1062368-62-0
2310134-98-4
Tags
available
drug candidate
Drug Status
experimental
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE
79
DESCRIPTION
LDN193189 (LDN-193189) (DM 3189) is a selective BMP signaling inhibitor, inhibiting the transcriptional activity of ALK2 and ALK3 (IC50s: 0.8/0.8/5.3/16.7 nM for ALK1/2/3/6).
PRICE
85
DESCRIPTION
LDN-193189 (dihydrochloride) is a potent selective BMP type I receptor (BMP I) inhibitor. LDN-193189 efficiently inhibits transcriptional activity of the BMP type I receptors ALK2 and ALK3 with IC50 values of 5 nM and 30 nM, respectively. LDN-193189 can be used for the research of bone morphogenetic protein signalling, such as fibrodysplasia ossificans progressiva[1][2][3].
PRICE
85
DESCRIPTION
LDN-193189 2HCl (DM-3189 2HCl) is a selective BMP signaling inhibitor that inhibits ALK1,ALK2,ALK3 and ALK6, showing IC50s of 0.8 nM, 0.8 nM, 5.3 nM, and 16.7 nM, respectively, in kinase assays.LDN-193189 2HCl inhibited the transcriptional activity of BMP type I receptors in C2C12 cells, with IC50s of 5 nM and 30 nM, respectively. LDN-193189 2HCl inhibited the transcriptional activity of BMP type I receptors ALK2 and ALK3 in C2C12 cells, with IC50s of 5 nM and 30 nM, respectively, and was 200-fold more selective for BMP than for TGF-??.
DESCRIPTION
LDN-193189 HCl (LDN193189 Hydrochloride) is a selective BMP type I receptor kinases inhibitor.
(TargetMol Bioactive Compound Library)
DESCRIPTION
Potent serine palmitoyl transferase inhibitor
(Tocris Bioactive Compound Library)
DESCRIPTION
LDN 193189 dihydrochloride is a selective ALK2 and ALK3 inhibitor with IC50 values of 5 and 30 nM. It can inhibit FOP and ectopic ossification. LDN 193189 is a potential agent in the treatment of NSCLC lung tumors.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
LDN-193189 2HCl (DM-3189 2HCl) is a selective BMP signaling inhibitor that inhibits ALK1,ALK2,ALK3 and ALK6, showing IC50s of 0.8 nM, 0.8 nM, 5.3 nM, and 16.7 nM, respectively, in kinase assays.LDN-193189 2HCl inhibited the transcriptional activity of BMP type I receptors in C2C12 cells, with IC50s of 5 nM and 30 nM, respectively. LDN-193189 2HCl inhibited the transcriptional activity of BMP type I receptors ALK2 and ALK3 in C2C12 cells, with IC50s of 5 nM and 30 nM, respectively, and was 200-fold more selective for BMP than for TGF-β.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
16
Axon Medchem Screening Library
BOC Sciences Bioactive Compounds
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
EU-OPENSCREEN Bioactive Compound Library
EUbOPEN Chemogenomics Library
LINCS compound set
LSP-MoA library (Laboratory of Systems Pharmacology)
Novartis Chemogenetic Library (NIBR MoA Box)
Selleckchem Bioactive Compound Library
Tocris Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
104
Molecular Weight
406.19
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
1
Rotatable Bonds
3
Ring Count
6
Aromatic Ring Count
5
cLogP
4.02
TPSA
58.35
Fraction CSP3
0.16
Chiral centers
0.0
Largest ring
6.0
QED
0.49
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
TGF-¦Â Receptor
ALK2
ALK3
TGF-??Receptor
ACVR1, BMPR1A
BMP inhibitor
Organoid
TGF-β Receptor
bone morphogenetic protein (BMP)
ALK1
ALK6
Pathway
Angiogenesis
Stem Cells
Tyrosine Kinase/Adaptors
Stem Cell/Wnt
TGF-beta/Smad
Primary Target
BMP and Other Activin Receptors
MOA
ALK
Inhibitor
Activin Receptor Like Kinase 3 (ALK3 BMPR-IA) Inhibitors
Activin Receptor Like Kinase 2 (ALK2 ActR-IA) Inhibitors
bone morphogenic protein inhibitor
Member status
member
Recommended Cell Concentration
100 nM
Source data
