General
Preferred name
BX 471
Synonyms
BX-471 ()
ZK-811752 ()
BX471 ()
ZK811752 ()
BX471 (hydrochloride) ()
BX 471 free base ()
ZK-811752 (hydrochloride) ()
ZK811752, BAY 865047, SH T 04268H ()
BX-741 ()
BAY-865047 ()
BAY-86-5047 ()
BAY86-5047 ()
P&D ID
PD013010
CAS
217645-70-0
288262-96-4
Tags
available
drug candidate
Drug indication
Discovery agent
Drug Status
investigational
Max Phase
Phase 2
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Potent, selective CCR1 antagonist.
DESCRIPTION
BX 471 is a potent, selective and orally active CCR1 antagonist .
(GtoPdb)
DESCRIPTION
Highly selective beta1-adrenoceptor antagonist
(Tocris Bioactive Compound Library)
DESCRIPTION
Potent, selective CCR1 antagonist
(Tocriscreen Plus)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
20
Axon Medchem Screening Library
Cayman Chemical Bioactives
ChEMBL Drugs
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
Drug Repurposing Hub
DrugMAP
EU-OPENSCREEN Bioactive Compound Library
Guide to Pharmacology
JUMP-Target 1 Compound Set
Mcule NIBR MoA Box Subset
Novartis Chemogenetic Library (NIBR MoA Box)
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
Tocris Bioactive Compound Library
Tocriscreen Plus
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
36
Molecular Weight
434.15
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
2
Rotatable Bonds
6
Ring Count
3
Aromatic Ring Count
2
cLogP
3.08
TPSA
87.9
Fraction CSP3
0.33
Chiral centers
1.0
Largest ring
6.0
QED
0.73
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
7-TM Receptors
Pathway
Immunology/Inflammation
Microbiology&virology
GPCR/G protein
Target
human CCR1
CCR1
CCR1 antagonist
CCR
Primary Target
Chemokine CC Receptors
MOA
Antagonist
Chemokine CCR1 Antagonists
CC chemokine receptor antagonist
Member status
member
Source data
