General
Preferred name
TORCETRAPIB
Synonyms
CP-529414 ()
Torcetrapib (CP-529414) ()
CP-529,414 ()
Torcetrapib ()
P&D ID
PD013009
CAS
262352-17-0
Tags
available
drug candidate
Drug indication
Peripheral vascular disease
Hyperlipidaemia
Familial hypercholesterolemia
Drug Status
withdrawn
investigational
Max Phase
3.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Torcetrapib (CP-529414) is a selective, potent cholesteryl ester transfer protein (CETP) inhibitor. A typical inhibition curve for whole human plasma, having a CETP concentration of 37 nM[1].
PRICE 67
DESCRIPTION Potent and selective MMP-3 inhibitor (Tocris Bioactive Compound Library)
DESCRIPTION Inhibitor of cholesteryl ester transfer protein (CETP) (Tocriscreen Plus)
DESCRIPTION Torcetrapib is an inhibitor of cholesteryl ester transfer protein. It is selective for CETP over phospholipid transfer protein (PLTP), lecithin cholesterol acyltransferase (LCAT), and hepatic and lipoprotein lipases at 10 ВµM. (Enamine Bioactive Compounds)
DESCRIPTION Torcetrapib (CP-529414) is a cholesteryl ester transfer protein (CETP) inhibitor designed to reduce the heterotypic transfer of cholesteryl ester from HDL to LDL and/or VLDL. It failed in phase III trials due to an excess of deaths. (TargetMol Bioactive Compound Library)
Cell lines
0
Organisms
2
Compound Sets
19
AdooQ Bioactive Compound Library
A11242
Axon Medchem Screening Library
2047
Cayman Chemical Bioactives
15028
ChEMBL Drugs
CHEMBL479527
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DB06281
DrugMAP
DMDHYM7
Enamine Bioactive Compounds
EBC-497104
EU-OPENSCREEN Bioactive Compound Library
EOS100480
Mcule NIBR MoA Box Subset
MCULE-3440168694
MedChem Express Bioactive Compound Library
HY-12089
Novartis Chemogenetic Library (NIBR MoA Box)
ReFrame library
Selleckchem Bioactive Compound Library
torcetrapib-cp-529414
TargetMol Bioactive Compound Library
T2499
Tocris Bioactive Compound Library
4184
Tocriscreen Plus
4184
Withdrawn 2.0
w254
External IDs
29
Properties
(calculated by RDKit )
Molecular Weight
600.17
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
0
Rotatable Bonds
5
Ring Count
3
Aromatic Ring Count
2
cLogP
8.2
TPSA
59.08
Fraction CSP3
0.46
Chiral centers
2.0
Largest ring
6.0
QED
0.32
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
CETP
CETP inhibitor
Target Type
Cell Biology
Primary Target
Other Transferases
MOA
Inhibitor
Cholesteryl Ester Transfer Protein (CETP) Inhibitors
cholesteryl ester transfer protein inhibitor
Member status
member
ATC
C
Toxicity type
cardiovascular
Pathway
Metabolism
Metabolic Enzyme/Protease
Source data