General
Preferred name
OPROZOMIB
Synonyms
PR-047 ()
ONX 0912 ()
ONX-0912 ()
P&D ID
PD013007
CAS
935888-69-0
Tags
available
covalent binder
nuisance
drug candidate
Drug indication
Multiple myeloma
Neoplasm
Hodgkin lymphoma
Solid tumour/cancer
Haematological malignancy
Drug Status
investigational
Max Phase
2.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Oprozomib (PR-047) is an orally bioavailable and selective peptide epoxyketone proteasome inhibitor with IC50s of 36 and 82 nM for proteasome (¦Â5) and immunoproteasome (LMP7), respectively. Oprozomib (ONX 0912) induces apoptosis in MM cells[1].
PRICE 179
DESCRIPTION Oprozomib (PR-047) (ONX 0912) , an inhibitor for CT-L activity of 20S proteasome ??5(IC50=36 nM)/LMP7(IC50=82 nM), is orally bioavailable. Oprozomib also has potential antineoplastic activity.
DESCRIPTION Oprozomib is an orally bioavailable derivative of , with similar biological action, i.e. inhibition of the chymotrypsin-like activity (a.k.a. β5 activity) of the proteasome . This is compound 58 in . (GtoPdb)
DESCRIPTION Oprozomib (PR-047) (ONX 0912) , an inhibitor for CT-L activity of 20S proteasome β5(IC50=36 nM)/LMP7(IC50=82 nM), is orally bioavailable. Oprozomib also has potential antineoplastic activity. (TargetMol Bioactive Compound Library)
Cell lines
3
Organisms
0
Compound Sets
15
AdooQ Bioactive Compound Library
A14181
Cayman Chemical Bioactives
16269
ChEMBL Drugs
CHEMBL2103884
CovBinderInPDB
CBR007382
CBR007381
CBR007380
CBR007379
CBR007378
CBR007377
CBR002775
CBR002774
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DB11991
DrugMAP
DM16RIC
EU-OPENSCREEN Bioactive Compound Library
EOS101484
Guide to Pharmacology
8739
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL2103884
MedChem Express Bioactive Compound Library
HY-12113
Nuisance compounds in cellular assays
ReFrame library
TargetMol Bioactive Compound Library
T6041
External IDs
24
Properties
(calculated by RDKit )
Molecular Weight
532.2
Hydrogen Bond Acceptors
9
Hydrogen Bond Donors
3
Rotatable Bonds
14
Ring Count
3
Aromatic Ring Count
2
cLogP
0.41
TPSA
148.25
Fraction CSP3
0.48
Chiral centers
4.0
Largest ring
6.0
QED
0.3
Structural alerts
1
Protein disruption
Proteosome inhibition
Nuisance compounds
Related compounds
Custom attributes
(extracted from source data)
Target
Apoptosis
Autophagy
Proteasome
20S proteasome
MOA
Proteasome inhibitor
Pathway
Proteases/Proteasome
Ubiquitination
Metabolic Enzyme/Protease
Source data