General
Preferred name
A-867744
Synonyms
A 867744 ()
P&D ID
PD013005
CAS
1000279-69-5
Tags
available
drug candidate
Drug indication
Discovery agent
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
A-867744 is a highly potent and selective type II positive allosteric modulator (PAM) of the alpha7 nicotinic acetylcholine receptors (nAChR) with an EC50 of 1.0 ¦ÌM[1].
PRICE
84
DESCRIPTION
A-867744 is an effective and selective type II positive allosteric modulator of the ??7 nAChR (EC50: 1.0 ??M).
DESCRIPTION
Selective KCa2 (SK) channel negative modulator; inhibits SK currents
(Tocris Bioactive Compound Library)
DESCRIPTION
Positive allosteric modulator of alpha7 nAChR
(Tocriscreen Plus)
DESCRIPTION
A-867744 is a positive allosteric modulator of α7 nAChRs (IC50 values are 0.98 and 1.12 μM for human and rat α7 receptor ACh-evoked currents respectively, in X. laevis oocytes). Displays no activity at 5-HT3A, α3β4 or α4β2 nAChRs.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
A-867744 is an effective and selective type II positive allosteric modulator of the α7 nAChR (EC50: 1.0 μM).
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
13
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
Drug Repurposing Hub
DrugMAP
Guide to Pharmacology
MedChem Express Bioactive Compound Library
TargetMol Bioactive Compound Library
Tocris Bioactive Compound Library
Tocriscreen Plus
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
18
Molecular Weight
402.08
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
1
Rotatable Bonds
5
Ring Count
3
Aromatic Ring Count
3
cLogP
4.35
TPSA
82.16
Fraction CSP3
0.15
Chiral centers
0.0
Largest ring
6.0
QED
0.64
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
nAChR
CHRNA3, CHRNA4, CHRNA7
α7 nAChR
Target Type
Ion Channels
Primary Target
Nicotinic (?7) Receptors
MOA
Modulator
acetylcholine receptor allosteric modulator
Pathway
Autophagy
Neuroscience
Membrane Transporter/Ion Channel
Neuronal Signaling
Source data
