General
Preferred name
Telaglenastat
Synonyms
CB-839 ()
CB 839 ()
CB839 ()
Telaglenastat (CB-839) ()
CB-839 hydrochloride ()
TELAGLENASTAT HYDROCHLORIDE ()
CB-839 ()
P&D ID
PD012997
CAS
1439399-58-2
Tags
available
drug candidate
Drug indication
Breast cancer
Renal cell carcinoma
Solid tumour/cancer
leukaemia
Drug Status
investigational
Max Phase
2.0
1.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION CB-839 is an investigational noncompetitive (allosteric) glutaminase inhibitor . It is one of the structures claimed in patent US8604016 , where it is compound 670. The anti-cancer activity of CB-839 was first reported in preclinical studies in triple-negative breast cancer (TNBC) cells in vitro and in vivo .
DESCRIPTION Telaglenastat (CB-839) is an investigational noncompetitive (allosteric) glutaminase inhibitor . It is one of the structures claimed in patent US8604016 , where it is compound 670. The anti-cancer activity of CB-839 was first reported in preclinical studies in triple-negative breast cancer (TNBC) cells in vitro and in vivo . (GtoPdb)
Cell lines
13
Organisms
0
Compound Sets
15
AdooQ Bioactive Compound Library
A14396
Cayman Chemical Bioactives
22038
ChEMBL Drugs
CHEMBL3639788
CHEMBL4594286
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DB15232
DrugMAP
DM094UH
EU-OPENSCREEN Bioactive Compound Library
EOS101174
Guide to Pharmacology
9053
Mcule NIBR MoA Box Subset
MCULE-8175885993
MedChem Express Bioactive Compound Library
HY-12248
Novartis Chemogenetic Library (NIBR MoA Box)
ReFrame library
Selleckchem Bioactive Compound Library
cb-839
TargetMol Bioactive Compound Library
T6797
External IDs
27
Properties
(calculated by RDKit )
Molecular Weight
571.16
Hydrogen Bond Acceptors
9
Hydrogen Bond Donors
2
Rotatable Bonds
12
Ring Count
4
Aromatic Ring Count
4
cLogP
4.55
TPSA
131.88
Fraction CSP3
0.27
Chiral centers
0.0
Largest ring
6.0
QED
0.24
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Metabolism
Autophagy
Metabolic Enzyme/Protease
Target
GLUT
GLS
Glutaminase
Autophagy,Glutaminase
Member status
member
MOA
Glutaminase Inhibitors
Glutaminase inhibitor
Source data