General
Preferred name
Ro 61-8048
Synonyms
P&D ID
PD012982
CAS
199666-03-0
Tags
available
drug candidate
Drug indication
Neurodegenerative disorder
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Ro 61-8048 is an orally active and selective inhibitor of kynurenine 3-hydroxylase, with an IC50 of 37 nM. Ro 61-8048 provokes a significant increase of extracellular kynurenic acid concentrations[1].
PRICE
64
DESCRIPTION
Potent PARP inhibitor
(Tocris Bioactive Compound Library)
DESCRIPTION
Potent kynurenine 3-monooxygenase (KMO) inhibitor
(Tocriscreen Plus)
DESCRIPTION
Ro 61-8048 is a potent and selective inhibitor of kynurenine hydroxylase with an IC50 value of 37 nM.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
14
AdooQ Bioactive Compound Library
Axon Medchem Screening Library
Cayman Chemical Bioactives
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugMAP
EU-OPENSCREEN Bioactive Compound Library
Mcule NIBR MoA Box Subset
MedChem Express Bioactive Compound Library
Novartis Chemogenetic Library (NIBR MoA Box)
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
Tocris Bioactive Compound Library
Tocriscreen Plus
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
23
Molecular Weight
421.04
Hydrogen Bond Acceptors
8
Hydrogen Bond Donors
1
Rotatable Bonds
7
Ring Count
3
Aromatic Ring Count
3
cLogP
3.54
TPSA
120.66
Fraction CSP3
0.12
Chiral centers
0.0
Largest ring
6.0
QED
0.46
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
Enzymes
Target
KMO
KMO inhibitor
hydroxylase
Primary Target
Kynurenine 3-monooxygenase
MOA
Inhibitor
Kynurenine 3-Monooxygenase Inhibitors
kynurenine 3-monooxygenase inhibitor
Member status
member
Pathway
Metabolic Enzyme/Protease
Metabolism
Source data
