General
Preferred name
DU-176b
Synonyms
EDOXABAN TOSYLATE HYDRATE ()
DU-176b tosylate Monohydrate ()
DU-176b monohydrate ()
Edoxaban (tosylate monohydrate) ()
Edoxaban Tosylate Monohydrate ()
DU-176b (monohydrate) ()
P&D ID
PD012962
CAS
912273-65-5
1229194-11-9
Tags
available
drug
Drug indication
Atrial fibrillation
Drug Status
approved
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Edoxaban (DU-176b) monohydrate is an orally active, highly potent, selective, and direct Factor Xa (FXa) inhibitor with Kis of 0.561 and 2.98 nM for free human FXa and prothrombinase. Edoxaban monohydrate exhibits more than 10,000-fold selectivity over other coagulation proteases. Edoxaban monohydrate can be used for preventing thromboembolic disease research[1].
PRICE 69
DESCRIPTION Edoxaban(DU-176) is an oral factor Xa (FXa) inhibitor in clinical development for stroke prevention. (TargetMol Bioactive Compound Library)
Compound Sets
6
AdooQ Bioactive Compound Library
A14317
DrugMAP
DMCIJBH
DrugMAP Approved Drugs
DMCIJBH
MedChem Express Bioactive Compound Library
HY-10264B
Selleckchem Bioactive Compound Library
edoxaban
TargetMol Bioactive Compound Library
T2368
External IDs
17
Properties
(calculated by RDKit )
Molecular Weight
737.21
Hydrogen Bond Acceptors
10
Hydrogen Bond Donors
4
Rotatable Bonds
6
Ring Count
5
Aromatic Ring Count
3
cLogP
1.71
TPSA
222.5
Fraction CSP3
0.42
Chiral centers
3.0
Largest ring
6.0
QED
0.21
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Factor Xa
Thrombin
Pathway
Metabolic Enzyme/Protease
Metabolism
Proteases/Proteasome
Source data