General
Preferred name
Pim1/AKK1-IN-1
Synonyms
LKB1/AAK1 dual inhibitor ()
MDK-2275 ()
P&D ID
PD012950
CAS
1093222-27-5
Tags
available
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Pim1/AKK1-IN-1 is a potent multi-kinase inhibitor with Kd values of 35 nM/53 nM/75 nM/380 nM for Pim1/AKK1/MST2/LKB1 respectively, and also inhibits MPSK1 and TNIK.
PRICE 228
DESCRIPTION Pim1/AKK1-IN-1 (LKB1/AAK1 dual inhibitor) is a potent multi-kinase inhibitor with Kd values of 35 nM/53 nM/75 nM/380 nM for Pim1/AKK1/MST2/LKB1 respectively, and also inhibits MPSK1 and TNIK. (TargetMol Bioactive Compound Library)
Cell lines
0
Organisms
2
Compound Sets
4
CZ-OPENSCREEN Bioactive Library
EU-OPENSCREEN Bioactive Compound Library
EOS100243
MedChem Express Bioactive Compound Library
HY-10371
TargetMol Bioactive Compound Library
T5093
External IDs
13
Properties
(calculated by RDKit )
Molecular Weight
339.11
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
2
Rotatable Bonds
3
Ring Count
4
Aromatic Ring Count
4
cLogP
3.75
TPSA
94.46
Fraction CSP3
0.0
Chiral centers
0.0
Largest ring
6.0
QED
0.59
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Target
MST2
Pim
Pim1
Pathway
JAK/STAT Signaling
Chromatin/Epigenetic
Stem Cells
Source data