General
Preferred name
Dapagliflozin propanediol monohydrate
Synonyms
Dapagliflozin Propylene Glycol ()
BMS-512148 (2S)-1,2-propanediol, hydrate ()
Dapagliflozin ((2S)-1,2-propanediol, hydrate)Dapagliflozin propanediol monohydrate ()
Dapagliflozin ((2S)-1,2-propanediol, hydrate) ()
DAPAGLIFLOZIN PROPANEDIOL ()
BMS-512148-05 ()
Dapagliflozin propylene glycolate hydrate ()
Edistride ()
Dapagliflozin propanediol component of xigduo ()
Dapagliflozin compound with (2s)-1,2-propanediol hydrate ()
Farxiga ()
Forxiga ()
Dapagliflozin propanediol ()
P&D ID
PD012944
CAS
960404-48-2
Tags
available
drug
Drug Status
approved
Max Phase
4.0
Drug indication
Heart failure
First approval
2012
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Dapagliflozin ((2S)-1,2-propanediol, hydrate) is the S-enantiomer of Dapagliflozin 1,2-propanediol, hydrate. Dapagliflozin ((2S)-1,2-propanediol, hydrate), a new type of agent used to treat diabetes mellitus (DM), is a competitive sodium/glucose cotransporter 2 (SGLT2) inhibitor, which results in excretion of glucose into the urine[1]. Dapagliflozin ((2S)-1,2-propanediol, hydrate) induces HIF1 expression and attenuates renal IR injury[2].
PRICE
37
DESCRIPTION
Dapagliflozin ((2S)-1,2-propanediol, hydrate) (BMS-512148 (2S)-1,2-propanediol, hydrate) is a selective, orally active inhibitor of the renal sodium-glucose co-transporter type 2 (SGLT2), in development for treating type 2 diabetes mellitus (T2DM). It inhibits SGLT2, responsible for at least 90% of glucose reabsorption in the kidney.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
5
ChEMBL Approved Drugs
ChEMBL Drugs
MedChem Express Bioactive Compound Library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
12
Molecular Weight
502.2
Hydrogen Bond Acceptors
8
Hydrogen Bond Donors
6
Rotatable Bonds
7
Ring Count
3
Aromatic Ring Count
2
cLogP
0.38
TPSA
171.34
Fraction CSP3
0.5
Chiral centers
6.0
Largest ring
6.0
QED
0.32
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
SGLT
SGLT2
Pathway
Membrane Transporter/Ion Channel
GPCR/G protein
Source data
