General
Preferred name
SU-014813
Synonyms
SU-14813 ()
SU14813 ()
SU14813 (maleate) ()
SU 014813 ()
SU14813 maleate ()
(Z)-SU14813 ()
P&D ID
PD012941
CAS
452105-23-6
627908-92-3
849643-15-8
Tags
available
drug candidate
obsolete probe
Drug Status
investigational
Max Phase
2.0
Drug indication
breast neoplasm
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION SU14813 maleate is a multi-targeted receptor tyrosine kinases inhibitor with IC50s of 50, 2, 4, 15 nM for VEGFR2, VEGFR1, PDGFR¦Â and KIT.
PRICE 643
DESCRIPTION (Z)-SU14813 is a novel tyrosine kinase inhibitor with anticardiogenic and antitumor activity that inhibits VEGFR-2, PDGFR-??, and FLT3 phosphorylation in xenograft tumors in a dose- and time-dependent manner.
DESCRIPTION SU14813 maleate is an oral, multitargeted tyrosine kinase inhibitor (TKI) targeting vascular endothelial growth factor receptors (VEGFR), platelet-derived growth factor receptors (PDGFR), Kit, and fms-like tyrosine kinase 3 (FLT-3). It was developed as a next-generation TKI agent following sunitinib (SU11248) designed to demonstrate optimized pharmacokinetic (PK) and tolerability profiles. It demonstrated broad and potent antitumor activity equivalent to that of sunitinib, which resulted in tumor regression, growth arrest, growth delay, and prolonged survival in established xenograft cancer models in mice. (BOC Sciences Bioactive Compounds)
DESCRIPTION (Z)-SU14813 is a novel tyrosine kinase inhibitor with anticardiogenic and antitumor activity that inhibits VEGFR-2, PDGFR-β, and FLT3 phosphorylation in xenograft tumors in a dose- and time-dependent manner. (TargetMol Bioactive Compound Library)
Compound Sets
12
AdooQ Bioactive Compound Library
A11557
BOC Sciences Bioactive Compounds
su14813-maleate-cas-849643-15-8-item-459836
ChEMBL Drugs
CHEMBL1721885
Clinical kinase drugs
Drug Repurposing Hub
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL1721885
LSP-OptimalKinase library (Laboratory of Systems Pharmacology)
CHEMBL1721885
MedChem Express Bioactive Compound Library
HY-10501A
Obsolete Compounds
su14813
ReFrame library
Selleckchem Bioactive Compound Library
su14813
TargetMol Bioactive Compound Library
T85345
External IDs
22
Properties
(calculated by RDKit )
Molecular Weight
442.2
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
4
Rotatable Bonds
6
Ring Count
4
Aromatic Ring Count
2
cLogP
2.91
TPSA
113.67
Fraction CSP3
0.39
Chiral centers
1.0
Largest ring
6.0
QED
0.41
Structural alerts
1
historic compounds (Chemical Probes.org)
Obsolete
Related compounds
Custom attributes
(extracted from source data)
Targets
FLT1,KDR,FLT4,PDGFRA,PDGFRB,KIT,FLT3
Target
tyrosine kinase
PDGFR
c-Kit
KDR
c-Kit,PDGFR,VEGFR
VEGFR
Pathway
Protein Tyrosine Kinase/RTK
Proteases/Proteasome
MOA
PDGFR tyrosine kinase receptor inhibitor, VEGFR inhibitor
Source data