General
Preferred name
SU-014813
Synonyms
SU-14813 ()
SU14813 ()
SU14813 (maleate) ()
SU14813 maleate ()
SU 014813 ()
P&D ID
PD012941
CAS
452105-23-6
627908-92-3
849643-15-8
Tags
available
obsolete probe
drug candidate
Drug Status
investigational
Max Phase
2.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
SU14813 maleate is an oral, multitargeted tyrosine kinase inhibitor (TKI) targeting vascular endothelial growth factor receptors (VEGFR), platelet-derived growth factor receptors (PDGFR), Kit, and fms-like tyrosine kinase 3 (FLT-3). It was developed as a next-generation TKI agent following sunitinib (SU11248) designed to demonstrate optimized pharmacokinetic (PK) and tolerability profiles. It demonstrated broad and potent antitumor activity equivalent to that of sunitinib, which resulted in tumor regression, growth arrest, growth delay, and prolonged survival in established xenograft cancer models in mice.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
11
AdooQ Bioactive Compound Library
BOC Sciences Bioactive Compounds
ChEMBL Drugs
Clinical kinase drugs
Drug Repurposing Hub
LSP-MoA library (Laboratory of Systems Pharmacology)
LSP-OptimalKinase library (Laboratory of Systems Pharmacology)
MedChem Express Bioactive Compound Library
Obsolete Compounds
ReFrame library
Selleckchem Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
23
Molecular Weight
442.2
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
4
Rotatable Bonds
6
Ring Count
4
Aromatic Ring Count
2
cLogP
2.91
TPSA
113.67
Fraction CSP3
0.39
Chiral centers
1.0
Largest ring
6.0
QED
0.41
Structural alerts
1
historic compounds (Chemical Probes.org)
Obsolete
Related compounds
Custom attributes
(extracted from source data)
Targets
FLT1,KDR,FLT4,PDGFRA,PDGFRB,KIT,FLT3
Pathway
Protein Tyrosine Kinase/RTK
Target
PDGFR
c-Kit
KDR
VEGFR
c-Kit,PDGFR,VEGFR
MOA
PDGFR tyrosine kinase receptor inhibitor, VEGFR inhibitor
Source data
