General
Preferred name
CJ-42794
Synonyms
CJ-042794 ()
RQ-00000008 ()
P&D ID
PD012919
CAS
847728-01-2
Tags
drug candidate
available
Drug indication
Inflammation
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION CJ-42794 (CJ-042794) is a potent, orally active, selective prostaglandin E receptor 4 (EP4) antagonist with an IC50 value of 10 nM, which is 200-fold more selective than EP1, EP2 and EP3. CJ-42794 can be used in research of gastric ulcers[1][2].
PRICE 43
DESCRIPTION This compound is a human EP4 receptor selective antagonist. (GtoPdb)
DESCRIPTION CJ-42794 is a selective prostaglandin E receptor subtype 4 (EP4) antagonist. It inhibits [3H]-PGE2 binding to the human EP4 receptor with a mean pKi of 8.5. It competitively antagonized cAMP accumulation with a pA2 value of 8.7 in HEK293 cells overexpressing rat prostanoid EP4 receptors. It did not exhibit any remarkable binding to 65 additional proteins, including GPCRs, enzymes, and ion channels. It reversed the inhibitory effects of PGE2 on LPS-induced TNFα production in a concentration-dependent manner. It has excellent pharmacological properties that make it a useful tool for exploring the physiological role of EP4 receptors . (BOC Sciences Bioactive Compounds)
DESCRIPTION CJ-42794 (CJ-042794) is a selective antagonist of the prostaglandin E receptor subtype 4 (EP4), inhibiting [3H]-PGE2 binding to the human EP4 receptor with a mean pKi of 8.5. It exhibits a binding affinity that is at least 200-fold more selective for the human EP4 receptor than for other human EP receptor subtypes (EP1, EP2, and EP3) (IC50: 8.5 (pKi)). (TargetMol Bioactive Compound Library)
Compound Sets
7
BOC Sciences Bioactive Compounds
cj-42794-cas-847728-01-2-item-424113
Cayman Chemical Bioactives
10010428
DrugMAP
DMP9V7U
EUbOPEN Chemogenomics Library
EUB0001846
Guide to Pharmacology
5857
MedChem Express Bioactive Compound Library
HY-10797
TargetMol Bioactive Compound Library
T14975
External IDs
18
Properties
(calculated by RDKit )
Molecular Weight
413.08
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
2
Rotatable Bonds
6
Ring Count
3
Aromatic Ring Count
3
cLogP
5.46
TPSA
75.63
Fraction CSP3
0.09
Chiral centers
1.0
Largest ring
6.0
QED
0.56
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Pathway
GPCR/G protein
Solubility
10 mM in DMSO
Recommended Cell Concentration
None
Target
Prostaglandin Receptor
Source data