General
Preferred name
SB 334867
Synonyms
SB334867A free base ()
SB-334867 ()
SB334867 ()
SB-334867 (free base) ()
SB 334867A ()
SB-334867 free base ()
P&D ID
PD012915
CAS
792173-99-0
249889-64-3
Tags
available
drug candidate
Drug indication
Discovery agent
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
SB‐334867 is a selective OX1R antagonist. Selective OX1R blockade is suggested as a pharmacological mechanism that offers clinical utility for the treatment of addiction or anxiety disorders .
(GtoPdb)
PRICE
73
DESCRIPTION
Potent, selective 5-HT6 antagonist
(Tocris Bioactive Compound Library)
DESCRIPTION
Selective non-peptide OX1 antagonist
(Tocriscreen Plus)
DESCRIPTION
Selective non-peptide OX1 antagonist
(Tocriscreen Total)
DESCRIPTION
SB-334867 free base (SB334867A free base) is a selective antagonist of the orexin-1 (OX1) receptor.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
19
AdooQ Bioactive Compound Library
Axon Medchem Screening Library
Cayman Chemical Bioactives
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
Drug Repurposing Hub
DrugMAP
EU-OPENSCREEN Bioactive Compound Library
Guide to Pharmacology
Novartis Chemogenetic Library (NIBR MoA Box)
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
Tocris Bioactive Compound Library
Tocriscreen Plus
Tocriscreen Total
ZINC Tool Compounds
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
31
Molecular Weight
319.11
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
2
Rotatable Bonds
2
Ring Count
4
Aromatic Ring Count
4
cLogP
3.72
TPSA
92.94
Fraction CSP3
0.06
Chiral centers
0.0
Largest ring
6.0
QED
0.59
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
7-TM Receptors
Target
OX Receptor
OX1
HCRTR1, HCRTR2
OX1 antagonist
Orexin Receptor (OX Receptor)
Primary Target
OX1 Receptors
MOA
OX Receptor antagonist
Antagonist
HCRTR1 antagonist
Orexin OX-1 Antagonists
orexin receptor antagonist
Member status
member
Pathway
GPCR/G protein
Neuronal Signaling
Neuroscience
Source data
