General
Preferred name
RS 504393
Synonyms
RS-504393 ()
RS504393 ()
P&D ID
PD012895
CAS
300816-15-3
Tags
available
drug candidate
Drug indication
Chronic obstructive pulmonary disease
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION RS-504393 is a highly selective CCR2 antagonist. (GtoPdb)
DESCRIPTION Highly selective CCR2 antagonist
DESCRIPTION RS 504393 is a selective CCR2 chemokine receptor antagonist (IC50 values are 89 nM and > 100 ¦ÌM for inhibition of human recombinant CCR2 and CCR1 receptors respectively).
PRICE 144
DESCRIPTION RS 504393 is a highly selective CCR2 chemokine receptor antagonist (IC50s: 89 nM and > 100 ??M for human recombinant CCR2 and CCR1).
DESCRIPTION Peripheral D2-like antagonist (Tocris Bioactive Compound Library)
DESCRIPTION Highly selective CCR2 chemokine receptor antagonist (Tocriscreen Total)
DESCRIPTION RS 504393 is a highly selective CCR2 chemokine receptor antagonist (IC50s: 89 nM and > 100 μM for human recombinant CCR2 and CCR1). (TargetMol Bioactive Compound Library)
Compound Sets
11
AdooQ Bioactive Compound Library
A15227
Cayman Chemical Bioactives
17330
Drug Repurposing Hub
DrugMAP
DMB9IPR
EU-OPENSCREEN Bioactive Compound Library
EOS101188
Guide to Pharmacology
781
MedChem Express Bioactive Compound Library
HY-15418
Selleckchem Bioactive Compound Library
rs504393
TargetMol Bioactive Compound Library
T5384
Tocris Bioactive Compound Library
2517
Tocriscreen Total
External IDs
23
Properties
(calculated by RDKit )
Molecular Weight
417.21
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
1
Rotatable Bonds
4
Ring Count
5
Aromatic Ring Count
3
cLogP
5.05
TPSA
67.6
Fraction CSP3
0.36
Chiral centers
0.0
Largest ring
6.0
QED
0.64
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
CCR
CCR2
CCL2, CCR2
Primary Target
Chemokine CC Receptors
MOA
Antagonist
CC chemokine receptor antagonist
Pathway
GPCR/G protein
Immunology/Inflammation
Microbiology/virology
Source data