General
Preferred name
alvelestat
Synonyms
AZD9668 ()
Avelestat ()
AZD-9668 ()
MPH-966 ()
Mph966 ()
AZD 9668 ()
P&D ID
PD012890
CAS
1240425-05-1
848141-11-7
Tags
available
drug candidate
Drug indication
Bronchiectasis
Chronic obstructive pulmonary disease
Drug Status
investigational
Max Phase
2.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION AZD9668 is a potent, selective and reversible inhibitor of human neutrophil elastase. It was developed as having the potential to be effective for neutrophil-driven inflammatory lung diseases, such as bronchiectasis and COPD . Since the phase II studies did not show clear efficacy for COPD this compound is now listed in the AstraZeneca Open Innovation Clinical Compound Bank for repurposing proposals.

There is ambiguity on PubChem in the assigned nomenclature and stuctures for this compound, as CID 71587812 has been incorrectly assigned alvelestat as a synonym. (GtoPdb)
DESCRIPTION Alvelestat (AZD9668) is an orally bioavailable, affinity and selective inhibitor of neutrophil elastase (NE) with a pIC50 value of 7.9 nM, a Ki value of 9.4 nM and a Kd value of 9.5 nM[1].
PRICE 85
DESCRIPTION Avelestat, also known as AZD9668, is a novel, oral inhibitor of neutrophil elastase (NE). (BOC Sciences Bioactive Compounds)
DESCRIPTION Alvelestat (AZD9668) is an orally bioavailable, selective, and reversible inhibitor of human neutrophil elastase (NE), exhibiting potential anti-inflammatory activity. (TargetMol Bioactive Compound Library)
Compound Sets
20
AdooQ Bioactive Compound Library
A12779
BOC Sciences Bioactive Compounds
alvelestat-cas-848141-11-7-item-84-462256
Cayman Chemical Bioactives
26083
ChEMBL Drugs
CHEMBL3617964
Concise Guide to Pharmacology 2017/18
6476
Concise Guide to Pharmacology 2019/20
6476
Concise Guide to Pharmacology 2021/22
6476
Concise Guide to Pharmacology 2023/24
6476
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DB11863
DrugMAP
DMB87M3
EU-OPENSCREEN Bioactive Compound Library
EOS101309
Guide to Pharmacology
6476
JUMP-Target 1 Compound Set
46861623
Mcule NIBR MoA Box Subset
MCULE-2332912933
MedChem Express Bioactive Compound Library
HY-15651
Novartis Chemogenetic Library (NIBR MoA Box)
ReFrame library
TargetMol Bioactive Compound Library
T3107
External IDs
26
Properties
(calculated by RDKit )
Molecular Weight
545.13
Hydrogen Bond Acceptors
8
Hydrogen Bond Donors
1
Rotatable Bonds
6
Ring Count
4
Aromatic Ring Count
4
cLogP
3.29
TPSA
115.95
Fraction CSP3
0.2
Chiral centers
0.0
Largest ring
6.0
QED
0.4
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Elastase
Neutrophil Elastase
ELANE
Member status
virtual
MOA
Elastase inhibitor
Pathway
Metabolic Enzyme/Protease
Proteases/Proteasome
Source data