General
Preferred name
Pidnarulex
Synonyms
CX-5461 ()
CX 5461 ()
CX-5461 (dihydrochloride) ()
Pidnarulex (CX-5461) ()
P&D ID
PD012876
CAS
1138549-36-6
Tags
available
nuisance
drug candidate
Drug Status
investigational
Max Phase
Phase 1
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
CX-5461 is an inhibitor of rRNA synthesis, selectively inhibits Pol I-driven transcription of rRNA with IC50 of 142 nM, has no effect on Pol II, and possesses 250- to 300-fold selectivity for inhibition of rRNA transcription versus DNA replication and protein translation.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
2
Organisms
0
Compound Sets
14
AdooQ Bioactive Compound Library
Axon Medchem Screening Library
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
ChEMBL Drugs
Drug Repurposing Hub
DrugBank
LINCS compound set
Nuisance compounds in cellular assays
Other bioactive compounds
ReFrame library
Selleckchem Bioactive Compound Library
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[[ ligand_id ]]
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External IDs
29
Molecular Weight
513.19
Hydrogen Bond Acceptors
9
Hydrogen Bond Donors
1
Rotatable Bonds
4
Ring Count
6
Aromatic Ring Count
5
cLogP
3.23
TPSA
95.73
Fraction CSP3
0.3
Chiral centers
0.0
Largest ring
7.0
QED
0.39
Structural alerts
2
Genotoxic
Nuisance compounds in cellular assays
Protein disruption
RNA polymerase inhibition
Nuisance compounds in cellular assays
Related compounds
Custom attributes
(extracted from source data)
Target
RNA Pol I
Pol I-driven transcription of rRNA
RNAP1 inhibitor
DNA/RNA Synthesis
MOA
RNA polymerase inhibitor
Pathway
Cell Cycle/DNA Damage
Source data
