General
Preferred name
bardoxolone methyl
Synonyms
CDDO-Me ()
Bardoxolone methyl (RTA 402) ()
RTA 402 ()
NSC 713200 ()
CDDO methyl ester ()
RTA 402, TP-155, NSC 713200, CDDO Methyl Ester, CDDO-Me ()
RTA402 ()
RTA-402 ()
CDDO-METHYL ESTER ()
Bardoxolone methyl ester ()
NSC-713200 ()
P&D ID
PD012875
CAS
218600-53-4
Tags
available
probe
drug candidate
Drug indication
Liver disease
Pulmonary hypertension
Pulmonary arterial hypertension
Mixed connective tissue disease
Drug Status
investigational
Max Phase
3.0
Probe info
Probe type
calculated probe
Probe sources
Probe targets
[[ compound.targets[t].gene_name ]]
Probe control
Probe control not defined
Orthogonal probes
1
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Bardoxolone methyl (NSC 713200; RTA 402; CDDO Methyl ester) is a synthetic triterpenoid compound with potential antineoplastic and anti-inflammatory activities, acting as an activator of the Nrf2 pathway and an inhibitor of the NF-¦ÊB pathway.
DESCRIPTION
Bardoxolone methyl is a synthetic triterpenoid. It is an activator of the Nrf2 pathway with potential antineoplastic and anti-inflammatory activities.
(Enamine Bioactive Compounds)
DESCRIPTION
HIF alpha-subunit inhibitor
(Tocris Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
20
Organisms
2
Compound Sets
20
AdooQ Bioactive Compound Library
Axon Medchem Screening Library
Cayman Chemical Bioactives
ChEMBL Drugs
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DrugMAP
Enamine Bioactive Compounds
Guide to Pharmacology
MedChem Express Bioactive Compound Library
Novartis Chemogenetic Library (NIBR MoA Box)
Probe Miner (suitable probes)
ReFrame library
Selleckchem Bioactive Compound Library
Tocris Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
26
Molecular Weight
505.32
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
0
Rotatable Bonds
1
Ring Count
5
Aromatic Ring Count
0
cLogP
6.38
TPSA
84.23
Fraction CSP3
0.75
Chiral centers
7.0
Largest ring
6.0
QED
0.39
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
NF-¦ÊB
NF-??
Anti-infection
NF-κB
Apoptosis
Autophagy
Primary Target
Nrf2
MOA
Activator
Angiogenesis Inhibitors
Antiinflammatory Drugs
Apoptosis Inducers
Bcl-2 Inhibitors
Glutathione Reductase (NADPH) Activators
Heme Oxygenase Activators
IKK-1 (IKK-alpha) Inhibitors
NF-kappaB (NFKB) Activation Inhibitors
Nitric Oxide Production Inhibitors
Nuclear Factor, Erythroid Derived 2, Like 2 (Nrf2) Activators
PPARgamma Agonists
nuclear factor erythroid derived, like (NRF2) activator
Member status
member
Target
I??/IKK
PPARG, STAT3
Apoptosis inducer
Keap1-Nrf2
SARS-CoV
Virus Protease
Apoptosis related,Autophagy,Ferroptosis,I¦ÊB/IKK,NF-¦ÊB,Nrf2
Ferroptosis
Source data
