General
Preferred name
ASP-3026
Synonyms
ASP 3026 ()
ASP3026 ()
Asp 3026 ()
P&D ID
PD012874
CAS
1097917-15-1
Tags
available
drug candidate
Drug indication
Diffuse large B-cell lymphoma
Drug Status
investigational
Max Phase
1.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
ASP-3026 is a second generation ALK inhibitor designed to target ALK rearrangements which are the oncogenic drivers of some non-small cell lung cancers (NSCLCs) and T-cell lymphomas known as ALK- expressing anaplastic large-cell lymphoma (ALK+ALCL) .
(GtoPdb)
DESCRIPTION
Potent anaplastic lymphoma kinase (ALK) inhibitor; also potent ACK inhibitor
(Tocriscreen Plus)
DESCRIPTION
Telomerase inhibitor
(Tocris Bioactive Compound Library)
DESCRIPTION
ASP3026 is a novel and selective inhibitor for the ALK kinase. ASP3026 potently inhibited ALK kinase activity and was more selective than crizotinib in a Tyr-kinase panel. In an anchorage independent in vitro cell growth assay, ASP3026 inhibited the growth of NCI-H2228, a human NSCLC tumor cell line endogenously expressing EML4-ALK variant 3 and that of 3T3 cells expressing EML4-ALK variant 1, 2 and 3.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
1
Organisms
0
Compound Sets
19
AdooQ Bioactive Compound Library
Axon Medchem Screening Library
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
ChEMBL Drugs
Clinical kinase drugs
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DrugMAP
EUbOPEN Chemogenomics Library
Guide to Pharmacology
LINCS compound set
MedChem Express Bioactive Compound Library
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
Tocris Bioactive Compound Library
Tocriscreen Plus
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
29
Molecular Weight
580.29
Hydrogen Bond Acceptors
11
Hydrogen Bond Donors
2
Rotatable Bonds
9
Ring Count
5
Aromatic Ring Count
3
cLogP
3.77
TPSA
115.82
Fraction CSP3
0.48
Chiral centers
0.0
Largest ring
6.0
QED
0.39
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
Enzyme-Linked Receptors
Targets
ALK
Pathway
Angiogenesis
Tyrosine Kinase/Adaptors
Apoptosis
Cell Cycle/DNA Damage
Epigenetics
JAK/STAT Signaling
MAPK/ERK Pathway
PI3K/Akt/mTOR
Protein Tyrosine Kinase/RTK
Stem Cell/Wnt
MOA
Inhibitor
ALK tyrosine kinase receptor inhibitor
Target
ALK inhibitor
Akt
Anaplastic lymphoma kinase (ALK)
Caspase
IGF-1R
JNK
PARP
ROS Kinase
STAT
Recommended Cell Concentration
100 nM
Source data
