General
Preferred name
PF-8380
Synonyms
PF 8380 ()
PF-8380 (hydrochloride) ()
P&D ID
PD012872
CAS
1144035-53-9
2070015-01-7
Tags
available
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
PF-8380 is reported as a novel autotaxin inhibitor for use as a tool compound for investigating the in vivo role of autotaxin and LPA in inflammation and in cancer . An ATX inhibitor compound named PF-8380 is claimed in patent WO2011151461 , but this has a different chemical structure from the entity we depict here and whch was disclosed in St-Coeur et al.'s primary publication .
(GtoPdb)
DESCRIPTION
PF-8380 is a potent autotaxin inhibitor with an IC50 of 2.8 nM in isolated enzyme assay and 101 nM in human whole blood.
PRICE
31
DESCRIPTION
PF-8380 hydrochloride is a potent autotaxin inhibitor with an IC50 of 2.8 nM in isolated enzyme assay and 101 nM in human whole blood.
DESCRIPTION
Potent and selective GSK-3beta inhibitor
(Tocris Bioactive Compound Library)
DESCRIPTION
PF-8380 is an effective and orally available autotaxin inhibitor (IC50: 2.8 nM, in isolated enzyme assay; 101 nM, in the human whole blood). It modulates lysophosphatidic acid (LPA) levels in vivo/vitro by directly inhibiting autotaxin; reduces LPA levels both in plasma and at the site of inflammation.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
5
Organisms
0
Compound Sets
10
Axon Medchem Screening Library
Cayman Chemical Bioactives
Drug Repurposing Hub
EU-OPENSCREEN Bioactive Compound Library
Guide to Pharmacology
Novartis Chemogenetic Library (NIBR MoA Box)
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
Tocris Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
26
Molecular Weight
477.09
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
1
Rotatable Bonds
6
Ring Count
4
Aromatic Ring Count
3
cLogP
3.96
TPSA
95.85
Fraction CSP3
0.32
Chiral centers
0.0
Largest ring
6.0
QED
0.54
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
autotaxin
phosphodiesterase
ENPP2
ATX inhibitor
Phosphodiesterase (PDE)
PDE
Primary Target
Autotaxin
MOA
Inhibitor
Ectonucleotide Pyrophosphatase/Phosphodiesterase 2 (ENPP2
Autotaxin) Inhibitors
Autotaxin inhibitor
Member status
member
Pathway
Metabolism
Metabolic Enzyme/Protease
Source data
