General
Preferred name
GSK126
Synonyms
GSK2816126A ()
Ezh2 inhibitor ()
GSK 126 ()
GSK2816126 ()
GSK-2816126 ()
GSK2816126A, GSK2816126 ()
P&D ID
PD012861
CAS
1346574-57-9
Tags
available
drug candidate
Drug indication
Solid tumour/cancer
Drug Status
investigational
Max Phase
1.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
GSK126 is a potent and selective small-molecule inhibitor of EZH2 (KMT6) methyltransferase activity . This is likely to be the ligand with the extended reseaerch code GSK2816126, which has anti-lymphoma potential.
(GtoPdb)
DESCRIPTION
Leucyl-tRNA synthase (TRS)/Ras-related GTP-binding protein D (RagD) interaction inhibitor
(Tocris Bioactive Compound Library)
DESCRIPTION
GSK126 is a potent, highly selective, S-adenosyl-methionine-competitive, small-molecule inhibitor of EZH2 methyltransferase activity. GSK126 decreases global H3K27me3 levels and reactivates silenced PRC2 target genes. GSK126 effectively inhibits the proliferation of EZH2 mutant DLBCL cell lines and markedly inhibits the growth of EZH2 mutant DLBCL xenografts in mice. Together, these data demonstrate that pharmacological inhibition of EZH2 activity may provide a promising treatment for EZH2 mutant lymphoma.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
18
Organisms
0
Compound Sets
16
AdooQ Bioactive Compound Library
Axon Medchem Screening Library
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
ChEMBL Drugs
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugMAP
EU-OPENSCREEN Bioactive Compound Library
Guide to Pharmacology
MedChem Express Bioactive Compound Library
Novartis Chemogenetic Library (NIBR MoA Box)
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
Tocris Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
21
Molecular Weight
526.31
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
3
Rotatable Bonds
7
Ring Count
5
Aromatic Ring Count
4
cLogP
4.63
TPSA
95.05
Fraction CSP3
0.39
Chiral centers
1.0
Largest ring
6.0
QED
0.33
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Chromatin/Epigenetic
Epigenetics
Target
EZH2
EZH2 HMTase inhibitor
Histone methyltransferase
EZH1/2,Histone Methyltransferase
MOA
Histone Methyltransferase inhibitor
Inhibitor
PRC2/EZH2
EZH2 gene inhibitor
histone lysine methyltransferase inhibitor
Member status
virtual
Source data
