General
Preferred name
ISRIB (trans-isomer)
Synonyms
ISRIB trans-isomer ()
trans-ISRIB ()
ISRIB ()
P&D ID
PD012842
CAS
1597403-47-8
Tags
available
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION ISRIB (trans-isomer) is a potent inhibitor of PERK with an IC50 of 5 nM. ISRIB potently reverses the effects of eIF2¦Á phosphorylation (IC50=5 nM).
PRICE 93
DESCRIPTION ISRIB (trans-isomer) is a potent inhibitor of PERK (IC50=5 nM) that restores protein translation and prevents SG formation in the presence of P-eIF2??.
DESCRIPTION Allosteric AMPK activator (Tocris Bioactive Compound Library)
DESCRIPTION ISRIB (trans-isomer) is a potent inhibitor of PERK (IC50=5 nM) that restores protein translation and prevents SG formation in the presence of P-eIF2α. (TargetMol Bioactive Compound Library)
Compound Sets
10
AdooQ Bioactive Compound Library
A13816
Axon Medchem Screening Library
2278
Cayman Chemical Bioactives
16258
Drug Repurposing Hub
MedChem Express Bioactive Compound Library
HY-12495
Novartis Chemogenetic Library (NIBR MoA Box)
Other bioactive compounds
Selleckchem Bioactive Compound Library
isrib-trans-isomer
TargetMol Bioactive Compound Library
T6183
Tocris Bioactive Compound Library
5284
External IDs
12
Properties
(calculated by RDKit )
Molecular Weight
450.11
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
2
Rotatable Bonds
8
Ring Count
3
Aromatic Ring Count
2
cLogP
3.99
TPSA
76.66
Fraction CSP3
0.36
Chiral centers
0.0
Largest ring
6.0
QED
0.64
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Apoptosis
Autophagy
Cell Cycle/DNA Damage
Primary Target
PERK
MOA
ERK inhibitor
Inhibits UPR, reactives translation
EIF2B4 modulator
eukaryotic translation initiation factor inhibitor, PERK inhibitor
Member status
member
Target
EIF2A, EIF2AK3
ISR inhibitor
Source data