General
Preferred name
ANA-12
Synonyms
ANA 12 ()
ANA12 ()
P&D ID
PD012841
CAS
219766-25-3
Tags
available
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION TrkB receptor antagonist (Tocriscreen Plus)
DESCRIPTION Selective FAAH inhibitor (Tocris Bioactive Compound Library)
DESCRIPTION ANA-12 is a selective TrkB antagonist. ANA-12 showed direct and selective binding to TrkB and inhibited processes downstream of TrkB without altering TrkA and TrkC functions. (BOC Sciences Bioactive Compounds)
Compound Sets
9
AdooQ Bioactive Compound Library
A13877
Axon Medchem Screening Library
2468
BOC Sciences Bioactive Compounds
ana-12-cas-219766-25-3-item-84-463338
Cayman Chemical Bioactives
14309
MedChem Express Bioactive Compound Library
HY-12497
Selleckchem Bioactive Compound Library
ana-12
TargetMol Bioactive Compound Library
T2359
Tocris Bioactive Compound Library
4781
Tocriscreen Plus
4781
External IDs
11
Properties
(calculated by RDKit )
Molecular Weight
407.13
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
3
Rotatable Bonds
4
Ring Count
4
Aromatic Ring Count
3
cLogP
3.55
TPSA
87.3
Fraction CSP3
0.23
Chiral centers
1.0
Largest ring
7.0
QED
0.62
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
Enzyme-Linked Receptors
Pathway
Tyrosine Kinase/Adaptors
Neuronal Signaling
Protein Tyrosine Kinase/RTK
Target
TrkB
TrkB antagonist
Trk Receptor
Primary Target
Trk Receptors
MOA
Antagonist
Source data