General
Preferred name
SD-208
Synonyms
SD 208 ()
ALK5 Inhibitor V ()
SD208 ()
P&D ID
PD012771
CAS
627536-09-8
1608481-61-3
Tags
available
drug candidate
Drug indication
Discovery agent
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
SD-208 is a selective, ATP-competitive inhibitor of TGFβR1 (ALK5) . SD-208 is compound 14 in patent WO2005032481 .
(GtoPdb)
DESCRIPTION
SD-208 is a selective TGF-¦ÂRI (ALK5) inhibitor with IC50 of 48 nM, and > 100-fold selectivity over TGF-¦ÂRII.
PRICE
57
DESCRIPTION
SD-208 (ALK5 Inhibitor V), a selective TGF-??RI (ALK5) inhibitor (IC50: 48 nM), is >100-fold selectivity over TGF-??RII.
DESCRIPTION
CYP2C19 substrate. Anticonvulsant
(Tocris Bioactive Compound Library)
DESCRIPTION
Potent ATP-competitive TGF-betaRI inhibitor
(Tocriscreen Plus)
DESCRIPTION
Potent ATP-competitive TGF-βRI inhibitor
(Tocriscreen Total)
DESCRIPTION
SD-208 (ALK5 Inhibitor V), a selective TGF-βRI (ALK5) inhibitor (IC50: 48 nM), is >100-fold selectivity over TGF-βRII.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
2
Compound Sets
14
AdooQ Bioactive Compound Library
Axon Medchem Screening Library
Drug Repurposing Hub
DrugMAP
EU-OPENSCREEN Bioactive Compound Library
EUbOPEN Chemogenomics Library
Guide to Pharmacology
MedChem Express Bioactive Compound Library
Novartis Chemogenetic Library (NIBR MoA Box)
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
Tocris Bioactive Compound Library
Tocriscreen Plus
Tocriscreen Total
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
19
Molecular Weight
352.06
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
1
Rotatable Bonds
3
Ring Count
4
Aromatic Ring Count
4
cLogP
4.02
TPSA
76.48
Fraction CSP3
0.0
Chiral centers
0.0
Largest ring
6.0
QED
0.6
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
Enzyme-Linked Receptors
Target
TGF-¦Â Receptor
TGF-??Receptor
TGFBR1
TGF-ßR1 inhibitor
TGF-β Receptor
TGF-βRI (ALK5)
Pathway
Stem Cells
TGF-beta/Smad
Primary Target
TGF-? Receptors
MOA
Inhibitor
Activin Receptor Like Kinase 5 (ALK5
TbetaR-I) Inhibitors
TGF beta receptor inhibitor
Member status
member
Recommended Cell Concentration
None
Source data
