General
Preferred name
BRIVARACETAM
Synonyms
UCB34714 ()
Briviact ()
Briviact (in italy: nubriveo) ()
Briviact (in italy: nubriveo) ()
UCB 34714 ()
UCB-34714 ()
P&D ID
PD012753
CAS
357336-20-0
Tags
available
probe
drug
Approved by
EMA
FDA
First approval
2016
Drug indication
Pain
Complex partial seizure
Epilepsy
Drug Status
approved
investigational
Max Phase
4.0
Probe info
Probe type
experimental probe
Probe sources
Probe targets
[[ compound.targets[t].gene_name ]]
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Brivaracetam is a 4-n-propyl analogue of with anticonvulsant properties . Like levetiracetam this drug inhibits synaptic vesicle protein 2A (SV2A), but with 10X higher binding affinity. Brivaracetam is brain penetrant and has a fast onset of action . It can also inhibit sodium channels.
(GtoPdb)
MOA
Inhibitor
(Chemical Probes.org)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
19
Cayman Chemical Bioactives
ChEMBL Approved Drugs
ChEMBL Drugs
Chemical Probes.org
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
CZ-OPENSCREEN Bioactive Library
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
Guide to Pharmacology
High-quality chemical probes
NCATS Inxight Approved Drugs
ReFrame library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
32
Molecular Weight
212.15
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
1
Rotatable Bonds
5
Ring Count
1
Aromatic Ring Count
0
cLogP
0.9
TPSA
63.4
Fraction CSP3
0.82
Chiral centers
2.0
Largest ring
5.0
QED
0.74
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
SV2A
Target class
Transporter
Target subclass
Glycoprotein
Source data
