General
Preferred name
AM679
Synonyms
P&D ID
PD012752
CAS
1206880-66-1
Tags
available
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION AM679 is a potent, selective 5-lipoxygenase-activating protein (FLAP) inhibitor with an IC50 of 2 nM in a human FLAP membrane binding assay. AM679 markedly reduces the respiratory syncytial virus-driven ocular pathology as well as the synthesis of cysteinyl leukotrienes (CysLTs) in the eye[1].
DESCRIPTION AM679 is a drug which acts as a selective inhibitor of 5-Lipoxygenase-activating protein (FLAP). This protein is involved in the production of cysteinyl leukotrienes which are involved in inflammation, and AM679 has anti-inflammatory effects in animal studies. AM679 also showed potent inhibition of leukotrienes in human blood and in a rodent bronchoalvelolar lavage (BAL) challenge model. Research showed AM679 reduces inflammation in the respiratory syncytial virus-infected mouse eye. (BOC Sciences Bioactive Compounds)
Compound Sets
5
BOC Sciences Bioactive Compounds
am679-cas-1206880-66-1-item-84-457591
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
EU-OPENSCREEN Bioactive Compound Library
EOS100260
MedChem Express Bioactive Compound Library
HY-14460
External IDs
14
Properties
(calculated by RDKit )
Molecular Weight
692.3
Hydrogen Bond Acceptors
8
Hydrogen Bond Donors
1
Rotatable Bonds
11
Ring Count
6
Aromatic Ring Count
5
cLogP
8.06
TPSA
106.78
Fraction CSP3
0.35
Chiral centers
1.0
Largest ring
6.0
QED
0.14
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
ALOX5AP, CNR1, CNR2
FLAP
MOA
cannabinoid receptor agonist, lipoxygenase inhibitor
Pathway
Immunology/Inflammation
Source data