General
Preferred name
CEVIPABULIN
Synonyms
TTI-237 ()
Cevipabulin (TTI-237) ()
Cevipabulin fumarate ()
TTI-237 fumarate ()
CEVIPABULIN SUCCINATE ()
Cevipabuline ()
Cevipabulina ()
TTI-237 SUCCINATE DIHYDRATE ()
TTI-237 FUMARATE DIHYDRATE ()
P&D ID
PD012713
CAS
849550-05-6
849550-69-2
849550-67-0
Tags
available
drug candidate
Drug Status
investigational
Max Phase
2.0
Drug indication
Neoplasm
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Cevipabulin (TTI-237) is an oral, microtubule-active antitumor compound and inhibits the binding of [3H] vinblastine to tubulin, with an IC50 of 18-40 nM for cytotoxicity in human tumor cell line[1][2].
PRICE
85
DESCRIPTION
Cevipabulin fumarate (TTI-237 fumarate) is an oral, microtubule-active, antitumor compound and inhibits the binding of [3H]NSC 49842 to tubulin, with an IC50 of 18-40 nM for cytotoxicity in human tumor cell line[1][2].
DESCRIPTION
Cevipabulin, is a small synthetic molecule of triazolopyrimidine derivative with potential antitumor activity. With a novel mechanism of action distinct from the action of other vinca alkaloid compounds, it specifically binds to tubulin at the vinca site, and promotes the polymerization of tubulin into microtubules. Cebipabulin stabilizes tubulin and inhibits microtubule disassembly. This results in cell cycle arrest at the G2/M phase, and leading to cell death.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
Cevipabulin (TTI-237) is a microtubule-active antitumor compound and inhibits the binding of [3H] vinblastine to tubulin (IC50: 18-40 nM in the human tumor cell line).
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
10
AdooQ Bioactive Compound Library
Axon Medchem Screening Library
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
ChEMBL Drugs
Drug Repurposing Hub
DrugBank
ReFrame library
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
39
Molecular Weight
464.12
Hydrogen Bond Acceptors
7
Hydrogen Bond Donors
2
Rotatable Bonds
8
Ring Count
3
Aromatic Ring Count
3
cLogP
4.07
TPSA
76.37
Fraction CSP3
0.39
Chiral centers
1.0
Largest ring
6.0
QED
0.3
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Microtubule
TUBB
Microtubule-active agent
Microtubule/Tubulin
MOA
microtubule stimulant, tubulin polymerization inhibitor
Pathway
Cytoskeletal Signaling
Cell Cycle/DNA Damage
cytoskeleton
Source data
