General
Preferred name
TCS 5861528
Synonyms
Chembridge-5861528 ()
P&D ID
PD012706
CAS
332117-28-9
Tags
available
drug candidate
Drug indication
Discovery agent
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Chembridge-5861528 (TCS 5861528) is a potent TRPA1 channel antagonist that antagonizes similarly allyl isothiocyanate- and 4-HNE-evoked TRPA1 responses, with IC50 values of 14.3 ¦ÌM and 18.7 ¦ÌM, respectively. Chembridge-5861528 shows antihypersensitivity activities[1].
PRICE 45
DESCRIPTION Chembridge-5861528 (TCS 5861528) is a TRPA1 channel blocker that inhibits AITC- and 4-HNE-induced calcium influx with IC50 values of 14.3 ??M and 18.7 ??M, respectively.
DESCRIPTION TCS 5861528 is a selective TRPA1 blocker with IC50 values are 14.3 and 18.7μM respectively), attenuates diabetes mellitus hypersensitivity and displays antinociceptive properties. (BOC Sciences Bioactive Compounds)
DESCRIPTION TRPA1 blocker (Tocriscreen Plus)
DESCRIPTION Chembridge-5861528 (TCS 5861528) is a TRPA1 channel blocker that inhibits AITC- and 4-HNE-induced calcium influx with IC50 values of 14.3 μM and 18.7 μM, respectively. (TargetMol Bioactive Compound Library)
DESCRIPTION Inhibitor of SOCE in non-excitable cells (Tocris Bioactive Compound Library)
Compound Sets
9
AdooQ Bioactive Compound Library
A14126
BOC Sciences Bioactive Compounds
tcs-5861528-cas-332117-28-9-item-272412
Cayman Chemical Bioactives
18380
DrugMAP
DMMUFSQ
Guide to Pharmacology
6276
MedChem Express Bioactive Compound Library
HY-15065
TargetMol Bioactive Compound Library
T2711
Tocris Bioactive Compound Library
3938
Tocriscreen Plus
3938
External IDs
13
Properties
(calculated by RDKit )
Molecular Weight
369.18
Hydrogen Bond Acceptors
7
Hydrogen Bond Donors
1
Rotatable Bonds
5
Ring Count
3
Aromatic Ring Count
3
cLogP
1.59
TPSA
90.92
Fraction CSP3
0.37
Chiral centers
1.0
Largest ring
6.0
QED
0.74
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
Ion Channels
Target
TRP Channel
TRPA1
MOA
Blocker
Pathway
Membrane Transporter/Ion Channel
Neuronal Signaling
Solubility
Soluble to 100 mM in DMSO and to 10 mM in ethanol
Source data