General
Preferred name
FANAPANEL
Synonyms
ZK 200775 ()
ZK200775 ()
MPQX ()
ZK200775 (hydrate) ()
MPQX (hydrate) ()
ZK-200775 ()
Fanapanel (hydrate) ()
ZK200775 hydrate ()
P&D ID
PD012705
CAS
161605-73-8
1255517-78-2
Tags
available
drug candidate
Drug indication
Coronary artery disease
Drug Status
investigational
Max Phase
2.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Competitive AMPA/kainate antagonist
(Tocriscreen Plus)
DESCRIPTION
Competitive AMPA/kainate antagonist
(Tocriscreen Total)
DESCRIPTION
Competitive AMPA/kainate antagonist. In rat cortical membranes, displays high affinity for [3H]-AMPA (Ki = 120 nM) and [3H]-CNQX (Ki = 32 nM) binding sites and low affinity for kainate and NMDA channel-associated binding sites (IC50 values range from 2.5 to 11 μM). Inhibits currents induced by AMPA, kainate and NMDA with IC50 values of 21 nM, 27 nM, and > 1 μM respectively. Displays anxiolytic, anticonvulsant and muscle relaxant activity in vivo.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
Potent and selective NMDA antagonist; acts at the glycine site
(Tocris Bioactive Compound Library)
DESCRIPTION
ZK200775 hydrate(Fanapanel; MPQX) is a highly selective AMPA/kainate antagonist with little activity against NMDA; have Ki values of 3.2 nM, 100 nM, and 8.5 μM against quisqualate, kainate, and NMDA, respectively.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
1
Compound Sets
12
BOC Sciences Bioactive Compounds
ChEMBL Drugs
Drug Repurposing Hub
DrugBank
DrugMAP
Guide to Pharmacology
NPC Screening Collection
ReFrame library
Tocris Bioactive Compound Library
Tocriscreen Plus
Tocriscreen Total
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
31
Molecular Weight
409.07
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
3
Rotatable Bonds
3
Ring Count
3
Aromatic Ring Count
2
cLogP
0.68
TPSA
124.86
Fraction CSP3
0.43
Chiral centers
0.0
Largest ring
6.0
QED
0.5
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
Ion Channels
Primary Target
AMPA Receptors
MOA
Antagonist
Kainate receptor antagonist
Pathway
Membrane Transporter/Ion Channel
Neuronal Signaling
Target
iGluR
Source data
