General
Preferred name
ASCOMYCIN
Synonyms
FK520 ()
Immunomycin ()
FR-900520 ()
FR 900520, Immunomycin ()
Ascomycin (FK520) ()
P&D ID
PD012698
CAS
104987-12-4
Tags
available
probe
Probe info
Probe type
calculated probe
Probe selectivity
protein-selective
Probe sources
Probe Miner (suitable probes)
Probe targets
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Ascomycin (Immunomycin; FR-900520; FK520) is an ethyl analog of Tacrolimus (FK506) with strong immunosuppressant properties. Ascomycin is also a macrocyclic polyketide antibiotic with multiple biological activities such as anti-malarial, anti-fungal and anti-spasmodic. Ascomycin prevents graft rejection and has potential for varying skin ailments research[1][2].
PRICE 53
DESCRIPTION Ascomycin (Immunomycin)(Immunomycin, FR-900520, FK520) is an ethyl analog of tacrolimus (FK506) with strong immunosuppressant properties. (TargetMol Bioactive Compound Library)
Cell lines
2
Organisms
2
Compound Sets
10
AdooQ Bioactive Compound Library
A12592
Cayman Chemical Bioactives
11309
Drug Repurposing Hub
EU-OPENSCREEN Bioactive Compound Library
EOS100968
MedChem Express Bioactive Compound Library
HY-13557
Novartis Chemogenetic Library (NIBR MoA Box)
Probe Miner (suitable probes)
P62942/975346
ReFrame library
Selleckchem Bioactive Compound Library
ascomycin-fk520
TargetMol Bioactive Compound Library
T2481
External IDs
24
Properties
(calculated by RDKit )
Molecular Weight
791.48
Hydrogen Bond Acceptors
12
Hydrogen Bond Donors
3
Rotatable Bonds
6
Ring Count
4
Aromatic Ring Count
0
cLogP
4.47
TPSA
178.36
Fraction CSP3
0.81
Chiral centers
14.0
Largest ring
21.0
QED
0.2
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Metabolism
Microbiology/virology
Anti-infection
Apoptosis
Autophagy
Cell Cycle/DNA Damage
Immunology/Inflammation
Member status
member
MOA
calcineurin inhibitor
FKBP12 gene modulator
"Calcineurin inhibitor
FKBP12 gene modulator"
Target
FKBP1A
antibiotic
FKBP
Fungal
Parasite
calcineurin phosphatase
Source data