General
Preferred name
daminozide
Synonyms
N-(Dimethylamino)Succinamic Acid ()
SUCCINIC ACID ()
DMASA ()
Aminozide ()
Daminozide-d4 ()
P&D ID
PD012692
CAS
1596-84-5
Tags
available
drug candidate
Drug indication
Discovery agent
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Daminozide was used as a plant growth regulator but was withdrawn from use following public concern over risks to health posed by long term exposure, although the evidence of the level of risk is controversial. Investigations are now under way to assess the utility of daminozide as a histone demethylase inhibitor .
(GtoPdb)
DESCRIPTION
Daminozide, a plant growth regulator, is a selective inhibitor of the human KDM2/7 histone demethylases, with IC50s of 0.55, 1.5 and 2.1 ¦ÌM for PHF8, KDM2A, and KIAA1718, respectively. Daminozide has >100-fold selectivity for KDM2/7 subfamily versus other demethylase subfamily members tested[1][2].
PRICE
29
DESCRIPTION
Selective KDM2/7 inhibitor
(Tocriscreen Plus)
DESCRIPTION
Daminozide is a highly selective inhibitor of the human 2-oxoglutarate (JmjC) histone demethylases KDM2A, PHF8, and KDM7A with IC50 values of 1.5, 0.55, and 2.1 μM, respectively. When tested for inhibition of other demethylase subfamily members (KDM3, KDM4, KDM5, KDM6) and other 2OG oxygenases (FIH, PHD2, BBOX1), daminozide was considerably less potent (IC50s > 100 μM). Daminozide is known to retard plant growth and was widely used in the 1960s for agricultural and horticultural applications to control plant size and fruit ripening before it was withdrawn because of carcinogenicity concerns.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
Daminozide (Succinic Acid) is a plant growth regulator, selectively inhibits the KDM2/7 JmjC subfamily.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
13
AdooQ Bioactive Compound Library
BOC Sciences Bioactive Compounds
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugMAP
EUbOPEN Chemogenomics Library
Guide to Pharmacology
LINCS compound set
LSP-MoA library (Laboratory of Systems Pharmacology)
MedChem Express Bioactive Compound Library
TargetMol Bioactive Compound Library
Tocriscreen Plus
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
31
Molecular Weight
160.08
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
2
Rotatable Bonds
4
Ring Count
0
Aromatic Ring Count
0
cLogP
-0.56
TPSA
69.64
Fraction CSP3
0.67
Chiral centers
0.0
Largest ring
0.0
QED
0.54
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
Enzymes
Target
Histone Demethylase
KDM2/7 JmjC
KDM2A, KDM7A, PHF8
MOA
KDM2A inhibitor
Pathway
Epigenetics
Chromatin/Epigenetic
Recommended Cell Concentration
None
Source data
