General
Preferred name
NOSCAPINE
Synonyms
Noscapine hydrchloride ()
NOSCAPINE HYDROCHLORIDE ()
Narcotine hydrochloride ()
(S,R)-Noscapine ()
noscapine, extended-release ()
Noscapina ()
Narcotine ()
(-)-narcotine ()
Narcotinum ()
Methoxyhydrastine ()
(-)-.alpha.-narcotine ()
NSC-5366 ()
Noscapinum ()
NSC-757235 ()
Noscapine hcl ()
Noscapine hydrochloride anhydrous ()
Noscapine (as hydrochloride) ()
Noscapine hydrochloride hydrate ()
Noscapine (hydrochloride) ()
Noscapine-13C-d3 ()
P&D ID
PD012688
CAS
912-60-7
128-62-1
1217680-57-3
Tags
available
drug
natural product
drug candidate
Drug Status
withdrawn
approved
investigational
Max Phase
4.0
Drug indication
Antitussive
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Noscapine is an alkaloid derived from the opium poppy Papaver somniferum, that has mild analgesic, antitussive, and potential antineoplastic activities. (GtoPdb)
DESCRIPTION Noscapine is often used as an antitussive medication. (BOC Sciences Bioactive Compounds)
DESCRIPTION Antitussive; naturally occurring opium alkaloid (LOPAC library)
DESCRIPTION Tubulin inhibitor; induces apoptosis (Tocriscreen Total)
Cell lines
7
Organisms
2
Compound Sets
19
BOC Sciences Bioactive Compounds
noscapine-cas-128-62-1-56782
Cayman Chemical Bioactives
17255
26679
ChEMBL Approved Drugs
CHEMBL364713
ChEMBL Drugs
CHEMBL364713
CHEMBL2106732
Drug Repurposing Hub
DrugBank
DB06174
DrugBank Approved Drugs
DB06174
DrugCentral
1973
DrugCentral Approved Drugs
1973
Guide to Pharmacology
10212
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL364713
MedChem Express Bioactive Compound Library
HY-13716
NPC Screening Collection
ReFrame library
TargetMol Bioactive Compound Library
T0981
Tocriscreen Total
Withdrawn 2.0
w5
ZINC Tool Compounds
ZINC000019418974
External IDs
63
Properties
(calculated by RDKit )
Molecular Weight
413.15
Hydrogen Bond Acceptors
8
Hydrogen Bond Donors
0
Rotatable Bonds
4
Ring Count
5
Aromatic Ring Count
2
cLogP
2.88
TPSA
75.69
Fraction CSP3
0.41
Chiral centers
2.0
Largest ring
6.0
QED
0.71
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Endocrinology/Hormones
GPCR/G protein
Neuroscience
Apoptosis
Neuronal Signaling
Target
Opioid alkaloid
SIGMAR1
Opioid Receptor
MOA
bradykinin receptor antagonist, tubulin polymerization inhibitor
Indication
cough suppressant
ATC
R05DA07
Toxicity type
carcinogenicity
Solubility
Chloroform, not in water
Source data