General
Preferred name
RESIQUIMOD
Synonyms
S28463 ()
R848 ()
Resiquimod (R-848) ()
CD11301 ()
S-28463 ()
R-848 ()
CD-11301 ()
P&D ID
PD012684
CAS
144875-48-9
Tags
available
drug candidate
Drug indication
Cutaneous T-cell lymphoma
Herpes simplex virus infection
Actinic keratosis
Drug Status
investigational
Max Phase
Phase 2
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Resiquimod (R-848) is a more potent derivative of the imidazoquinoline compound . It acts as a TLR7 agonist.
(GtoPdb)
DESCRIPTION
Toll-like receptor 7 (TLR7) agonist
(Tocriscreen Plus)
DESCRIPTION
Carnitine palmitoyltransferase I (CPT1) inhibitor
(Tocris Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
1
Compound Sets
23
AdooQ Bioactive Compound Library
Cayman Chemical Bioactives
ChEMBL Drugs
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
Drug Repurposing Hub
DrugBank
DrugMAP
DrugMatrix
EU-OPENSCREEN Bioactive Compound Library
Guide to Pharmacology
LSP-MoA library (Laboratory of Systems Pharmacology)
MedChem Express Bioactive Compound Library
Novartis Chemogenetic Library (NIBR MoA Box)
Pandemic Response Box
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
Tocris Bioactive Compound Library
Tocriscreen Plus
ZINC Tool Compounds
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
31
Molecular Weight
314.17
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
2
Rotatable Bonds
5
Ring Count
3
Aromatic Ring Count
3
cLogP
2.47
TPSA
86.19
Fraction CSP3
0.41
Chiral centers
0.0
Largest ring
6.0
QED
0.76
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
Enzyme-Linked Receptors
Pathway
Immunology/Inflammation
Anti-infection
Target
TLR7
TLR8
TLR7, TLR8
HCV
Toll-like Receptor (TLR)
HCV,IFN,Interleukins,TLR,TNF-alpha
Primary Target
Toll-like Receptors
MOA
Agonist
Interferon Inducers
TLR7 Receptor Agonists
TLR8 Receptor Agonists
TNF-alpha Production Inducers
toll-like receptor agonist
Member status
member
Source data
