General
Preferred name
NSI-189
Synonyms
NSI 189 ()
NSI189 Phosphate ()
NSI 189 Phosphate ()
Amdiglurax ()
Amdiglurax (phosphate) ()
NSI-189 (phosphate) ()
NSI189 ()
NSI-189 PHOSPHATE ()
P&D ID
PD012652
CAS
1270138-40-3
1270138-41-4
Tags
available
drug candidate
Drug Status
investigational
Max Phase
2.0
1.0
Drug indication
depressive disorder
Major depressive disorder
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
NSI-189 is an orally active chemical entity with enhanced neurogenic activity. NSI-189 up-regulates neurogenic factors such as BDNF (brain derived-neurotrophic factor) and SCF. NSI-189 exhibits anti-depressant effect. NSI-189 enhances synaptic plasticity and reduces cognitive dysfunction. NSI-189 holds potential for psychiatric disorder research[1][2][3].
PRICE
32
DESCRIPTION
NSI-189 is an orally active chemical entity with enhanced neurogenic activity. NSI-189 up-regulates neurogenic factors such as BDNF (brain derived-neurotrophic factor) and SCF. NSI-189 exhibits anti-depressant effect. NSI-189 enhances synaptic plasticity and reduces cognitive dysfunction. NSI-189 holds potential for psychiatric disorder research[1][2][3].
PRICE
42
DESCRIPTION
NSI189 (NSI-189) is a nootropic and neurogenic research chemical derived from nicotinamide and pyrazine.
(TargetMol Bioactive Compound Library)
DESCRIPTION
NSI-189 Phosphate is a novel neurogenic molecule with pleiotropic properties, including antidepressant, procognitive, synaptoplastic, and neurotrophic activities demonstrated in preclinical studies. Its antidepressant activity is monoamine-independent.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
9
AdooQ Bioactive Compound Library
Cayman Chemical Bioactives
ChEMBL Drugs
Drug Repurposing Hub
DrugBank
MedChem Express Bioactive Compound Library
ReFrame library
Selleckchem Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
24
Molecular Weight
366.24
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
1
Rotatable Bonds
7
Ring Count
3
Aromatic Ring Count
2
cLogP
3.5
TPSA
48.47
Fraction CSP3
0.45
Chiral centers
0.0
Largest ring
6.0
QED
0.81
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
MOA
neurotrophic agent
Target
Trk Receptor
Pathway
Neuronal Signaling
Protein Tyrosine Kinase/RTK
Source data
