General
Preferred name
LAZABEMIDE
Synonyms
LAZABEMIDE HYDROCHLORIDE ()
N-(2-Aminoethyl)-5-chlor-2-pyridincarbox ()
Ro 19-6327 ()
Lazabemide hydrate ()
RO-19-6327/000 ()
RO 19-6327/000 ()
Ro-196327 ()
Lazabemida ()
Tempium ()
Lazabemide monohydrochloride ()
RO 19-6327/001 ()
Lazabemide hcl ()
RO-196327001 ()
RO-19-6327/001 ()
P&D ID
PD012645
CAS
103878-83-7
103878-84-8
Tags
available
drug candidate
Drug indication
Skin imperfections
Cognitive impairment
Drug Status
investigational
Max Phase
2.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Lazabemide (Ro 19-6327) is a selective, reversible inhibitor of monoamine oxidase B (MAO-B) (IC50=0.03 ¦ÌM) but less active for MAO-A (IC50>100 ¦ÌM). Lazabemide inhibits monoamine uptake at high concentrations, the IC50 values are 86 ¦ÌM, 123 ¦ÌM and >500 ¦ÌM for noradrenalin, serotonin and dopamine uptake, respectively. Lazabemide can be used for the research of parkinson and alzheimer¡äs disease[1].
PRICE 41
DESCRIPTION Lazabemide, a pyridine derivative, is a reversible and selective monoamine oxidase B inhibitor that has probable effect for Parkinson's disease. IC50: 30 nM. It could also influence the absorption of some monoamines like noradrenalin, serotonin and dopami (BOC Sciences Bioactive Compounds)
DESCRIPTION Selective MAO-B inhibitor (Tocriscreen Plus)
DESCRIPTION Selective MAO-B inhibitor (Tocriscreen Total)
DESCRIPTION Lazabemide is a monoamine oxidase B inhibitor with IC50 values of 0.03 and > 100 μM for MAO-B and MAO-A. It is potentially an antiparkinsonian agent. (BOC Sciences Bioactive Compounds)
DESCRIPTION Selective Syk kinase inhibitor (Tocris Bioactive Compound Library)
DESCRIPTION Lazabemide hydrochloride is a selective, reversible inhibitor of monoamine oxidase B. Lazabemide can be used for the research of parkinson and alzheimer disease. (Enamine Bioactive Compounds)
DESCRIPTION Lazabemide hydrochloride (N-(2-Aminoethyl)-5-chlor-2-pyridincarbox) is a reversible and selective mao-b inhibitor(Ki:7.9nM). (TargetMol Bioactive Compound Library)
Compound Sets
24
BOC Sciences Bioactive Compounds
lazabemide-hydrate-cas-103878-84-8-358128
lazabemide-hydrochloride-cas-103878-83-7-item-159420
Cayman Chemical Bioactives
11640
ChEMBL Drugs
CHEMBL279390
CHEMBL2105029
Concise Guide to Pharmacology 2017/18
6640
Concise Guide to Pharmacology 2019/20
6640
Concise Guide to Pharmacology 2021/22
6640
Concise Guide to Pharmacology 2023/24
6640
Drug Repurposing Hub
DrugMAP
DMCULK7
DrugMatrix
Enamine Bioactive Compounds
EBC-06422
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
EOS101560
Guide to Pharmacology
6640
Mcule NIBR MoA Box Subset
MCULE-7045156412
MedChem Express Bioactive Compound Library
HY-14201
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
ReFrame library
Selleckchem Bioactive Compound Library
lazabemide
TargetMol Bioactive Compound Library
T5678
Tocris Bioactive Compound Library
2460
Tocriscreen Plus
2460
Tocriscreen Total
External IDs
40
Properties
(calculated by RDKit )
Molecular Weight
199.05
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
2
Rotatable Bonds
3
Ring Count
1
Aromatic Ring Count
1
cLogP
0.42
TPSA
68.01
Fraction CSP3
0.25
Chiral centers
0.0
Largest ring
6.0
QED
0.74
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
Enzymes
Pathway
Metabolism
Neuroscience
Neuronal Signaling
Primary Target
Monoamine Oxidases
MOA
Inhibitor
"Monoamine Oxidase
MAO-B Inhibitors
monoamine oxidase inhibitor
Member status
member
Target
MAOB
Monoamine Oxidase
MAO
MAO-B
Solubility
DMSO: > 34 mg/mL
Source data