General
Preferred name
Oglemilast
Synonyms
GRC 3886 ()
GRC 3845 ()
P&D ID
PD012630
CAS
778576-62-8
Tags
available
drug candidate
Drug indication
Chronic obstructive pulmonary disease
Asthma
Drug Status
investigational
Max Phase
2.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE
152
DESCRIPTION
Oglemilast is a potent PDE4 inhibitor and under clinical studies in the treatment of allergen-induced asthma.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
Oglemilast (GRC 3886) suppresses pulmonary cell infiltration, including eosinophilia and neutrophilia in vitro and in vivo. Oglemilast is an effective and orally active phosphodiesterase-4 (PDE4) inhibitor (IC50: 0.5 nM for PDE4D3). Oglemilast has the potential for inflammatory airway diseases.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
9
BOC Sciences Bioactive Compounds
ChEMBL Drugs
Drug Repurposing Hub
DrugBank
DrugMAP
EUbOPEN Chemogenomics Library
MedChem Express Bioactive Compound Library
ReFrame library
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
18
Molecular Weight
514.99
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
2
Rotatable Bonds
6
Ring Count
4
Aromatic Ring Count
4
cLogP
5.51
TPSA
110.53
Fraction CSP3
0.1
Chiral centers
0.0
Largest ring
6.0
QED
0.35
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
PDE4D
Phosphodiesterase (PDE)
MOA
phosphodiesterase inhibitor
Pathway
Metabolism
Metabolic Enzyme/Protease
Recommended Cell Concentration
None
Source data
