General
Preferred name
Nutlin-3b
Synonyms
nutlin-3 ()
Nutlin (3) ()
(+)-Nutlin-3 ()
P&D ID
PD012598
CAS
675576-97-3
548472-68-0
Tags
available
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION MDM2 antagonist; inhibits MDM2-p53 interaction (Tocriscreen Plus)
DESCRIPTION Potent Aurora kinase B inhibitor (Tocris Bioactive Compound Library)
Cell lines
5
Organisms
0
Compound Sets
7
Axon Medchem Screening Library
1585
1881
Cayman Chemical Bioactives
10009816
MedChem Express Bioactive Compound Library
HY-15335
HY-50696
Selleckchem Bioactive Compound Library
nutlin-3b
TargetMol Bioactive Compound Library
T6614
Tocris Bioactive Compound Library
3984
Tocriscreen Plus
3984
External IDs
21
Properties
(calculated by RDKit )
Molecular Weight
580.16
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
1
Rotatable Bonds
6
Ring Count
5
Aromatic Ring Count
3
cLogP
5.89
TPSA
83.47
Fraction CSP3
0.3
Chiral centers
2.0
Largest ring
6.0
QED
0.39
Structural alerts
1
historic compounds (Chemical Probes.org)
Obsolete
Related compounds
Custom attributes
(extracted from source data)
Target Type
Enzymes
Pathway
Apoptosis
Metabolic Enzyme/Protease
Target
MDM2
MDM2 inhibitor
E1/E2/E3 Enzyme
MDM-2/p53
MDM2/MDMX
Primary Target
Ubiquitin E3 Ligases
MOA
Inhibitor
Source data