General
Preferred name
FRENTIZOLE
Synonyms
Mono-hydrate of frentizole ()
Frentizol ()
3-(6-methoxy-1,3-benzothiazol-2-yl)-1-phenylurea ()
Compound 53616 ()
COMPOUND-53616 ()
P&D ID
PD012592
CAS
26130-02-9
Tags
available
drug candidate
Drug Status
investigational
Max Phase
2.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Frentizole, an FDA-approved immunosuppressant, is a A¦Â-ABAD (binding alcohol dehydrogenase) interaction inhibitor with an IC50 value of 200 ¦ÌM. Frentizole is used in studies of diseases related to rheumatoid arthritis and systemic lupus erythematosus[1][2][3].
PRICE
48
DESCRIPTION
Frentizole, an immunosuppressive agent, is an inhibitor of the A??-ABAD interaction
DESCRIPTION
Frentizole is a nontoxic antiviral and immunosuppressive agent used clinically in rheumatoid arthritis and systemic lupus erythematosus. Frentizole is a novel inhibitor of amyloid beta peptide binding alcohol dehydrogenase interaction.
(Enamine Bioactive Compounds)
DESCRIPTION
PUBCHEM_BIOASSAY: qHTS Assay for Modulators of miRNAs and/or Inhibitors of miR-21. (Class of assay: confirmatory)
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
10
ChEMBL Drugs
Drug Repurposing Hub
DrugMatrix
Enamine Bioactive Compounds
Enamine BioReference Compounds
MedChem Express Bioactive Compound Library
NPC Screening Collection
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
24
Molecular Weight
299.07
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
2
Rotatable Bonds
3
Ring Count
3
Aromatic Ring Count
3
cLogP
3.95
TPSA
63.25
Fraction CSP3
0.07
Chiral centers
0.0
Largest ring
6.0
QED
0.77
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Amyloid-¦Â
Amyloid-β
Beta Amyloid
MOA
Immunosuppressant
Pathway
Neuronal Signaling
Source data
