General
Preferred name
KAEMPFERIDE
Synonyms
Kaempferol 4'-O-methyl ether ()
Kaempferol 4'-methyl ether ()
4'-Methylkaempferol ()
4'-O-Methylkaempferol ()
4'-Methylkaempferol, 4'-O-Methylkaempferol, Kaempferol 4'-methyl ether ()
P&D ID
PD012582
CAS
491-54-3
Tags
available
drug candidate
Drug indication
Discovery agent
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Kaempferide is an orally active flavonol isolated from Hippophae rhamnoides L. Kaempferide has anticancer, anti-inflammatory, antioxidant, antidiabetic, antiobesity, antihypertensive, and neuroprotective activities. Kaempferide induces apoptosis. Kaempferide promotes osteogenesis through antioxidants and can be used in osteoporosis research[1][2][3][4][5][6].
PRICE 40
DESCRIPTION kaempferide (4'-Methylkaempferol) inhibits the proliferation of native and estrogen receptor beta overexpressing colon cancer cells through a mechanism not mediated by ligand binding dependent estrogen receptor activation. (TargetMol Bioactive Compound Library)
Cell lines
5
Organisms
0
Compound Sets
7
Cayman Chemical Bioactives
29673
DrugMAP
DMUWA2G
EU-OPENSCREEN Bioactive Compound Library
EOS100284
MedChem Express Bioactive Compound Library
HY-15449
Selleckchem Bioactive Compound Library
kaempferide
TargetMol Bioactive Compound Library
T3806
ZINC Tool Compounds
ZINC000006411540
External IDs
36
Properties
(calculated by RDKit )
Molecular Weight
300.06
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
3
Rotatable Bonds
2
Ring Count
3
Aromatic Ring Count
3
cLogP
2.59
TPSA
100.13
Fraction CSP3
0.06
Chiral centers
0.0
Largest ring
6.0
QED
0.67
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Pathway
Autophagy
Endocrinology/Hormones
Microbiology/virology
Anti-infection
Metabolic Enzyme/Protease
PI3K/Akt/mTOR
Stem Cell/Wnt
Vitamin D Related/Nuclear Receptor
Target
Akt
Apoptosis
Bacterial
Estrogen Receptor/ERR
FOXO
GSK-3
Influenza Virus
PI3K
β-catenin
EGFR
¦Â-catenin
ER
Source data