General
Preferred name
SALINOMYCIN
Synonyms
Sodium salinomycin ()
SALINOMYCIN SODIUM ()
Procoxacin ()
Coxistac, Bio-cox ()
Salinomycin (sodium salt) ()
Coxistac, Bio-cox, Procoxacin ()
Salinomycin (from Streptomyces albus) ()
Salinomycin sodium salt ()
Salinomicina ()
E716 ()
Salinomycine ()
P&D ID
PD012551
CAS
55721-31-8
53003-10-4
Tags
available
drug
Approved by
FDA
Drug Status
vet_approved
approved
investigational
Max Phase
2.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Salinomycin sodium salt (Salinomycin sodium), an antibiotic potassium ionophore, is a potent inhibitor of Wnt/¦Â-catenin signaling. Salinomycin sodium salt acts on the Wnt/Fzd/LRP complex, blocks Wnt-induced LRP6 phosphorylation, and causes degradation of the LRP6 protein. Salinomycin sodium salt shows selective activity against human cancer stem cells[1][2][3].
PRICE
40
DESCRIPTION
Salinomycin sodium salt (Sodium salinomycin), an antibiotic potassium ionophore, is an effective inhibitor of Wnt/??-catenin signaling.
DESCRIPTION
Salinomycin is an ionophore antibacterial, from which was derived. It is primarily used in veterinary practice. Salinomycin has potent antimicrobial activity against Gram-positive bacteria and is inactive against Gram-negative bacteria .
(GtoPdb)
DESCRIPTION
Salinomycin (Procoxacin), a polyether potassium ionophore antibiotic, selectively inhibits the growth of gram-positive bacteria. Salinomycin is a potent inhibitor of Wnt/¦Â-catenin signaling, blocks Wnt-induced LRP6 phosphorylation. Salinomycin shows selective activity against human cancer stem cells[1][2][3].
PRICE
151
DESCRIPTION
Salinomycin (Procoxacin), a polyether potassium ionophore antibiotic, specifically inhibits the growth of gram-positive bacteria, acts as a potent inhibitor of Wnt/??-catenin signaling by blocking Wnt-induced LRP6 phosphorylation, and demonstrates selective activity against human cancer stem cells.
DESCRIPTION
Salinomycin sodium salt (Sodium salinomycin), an antibiotic potassium ionophore, is an effective inhibitor of Wnt/β-catenin signaling.
(TargetMol Bioactive Compound Library)
DESCRIPTION
Salinomycin (Procoxacin), a polyether potassium ionophore antibiotic, specifically inhibits the growth of gram-positive bacteria, acts as a potent inhibitor of Wnt/β-catenin signaling by blocking Wnt-induced LRP6 phosphorylation, and demonstrates selective activity against human cancer stem cells.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
32
Organisms
8
Compound Sets
12
Cayman Chemical Bioactives
ChEMBL Drugs
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
Guide to Pharmacology
Other bioactive compounds
Selleckchem Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
49
Molecular Weight
750.49
Hydrogen Bond Acceptors
10
Hydrogen Bond Donors
4
Rotatable Bonds
12
Ring Count
5
Aromatic Ring Count
0
cLogP
6.19
TPSA
161.21
Fraction CSP3
0.9
Chiral centers
18.0
Largest ring
6.0
QED
0.17
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
¦Â-catenin
Antibacterial
Wnt/β-catenin
??catenin
antibiotic
Bacterial
Mitophagy
Parasite
Wnt
β-catenin
Wnt/beta-catenin
Pathway
Apoptosis
Autophagy
Cytoskeletal Signaling
Microbiology/virology
Stem Cells
Anti-infection
Stem Cell/Wnt
Indication
coccidiosis
Source data
