General
Preferred name
DORDAVIPRONE
Synonyms
ONC-201 ()
TIC10 ()
TIC 10 active isomer ()
ONC201 ()
NSC-350625 ()
TIC10 (ONC201) ()
DORDAVIPRONE HYDROCHLORIDE ()
Onc201 ()
TIC-10 ()
Onc 201 ()
Dordaviprona ()
ONC201 hydrochloride ()
ONC-201 DIHYDROCHLORIDE ()
TIC10 hydrochloride ()
Dordaviprone dihydrochloride ()
ONC201 DIHYDROCHLORIDE ()
P&D ID
PD012547
CAS
1342897-86-2
1616632-77-9
Tags
available
obsolete probe
drug
drug candidate
Drug indication
Endometrial cancer
Recurring respiratory infection
Multiple myeloma
Neoplasm
Solid tumour/cancer
leukaemia
Glioma
Glioblastoma multiforme
Neuroendocrine cancer
Lymphoma
Drug Status
approved
investigational
Max Phase
1.0
3.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Dordaviprone (ONC201, also known as TIC10 ) was originally discovered as a TRAIL pathway inducer and as an orally active dual Akt/ERK inhibitor . It exerts potent anti-tumour effects .
ONC201 was later reported as an allosteric activator of the oncology drug target, mitochondrial protease caseinolytic protease P (ClpP) . It also antagonises dopamine D2/3 receptor signalling . (GtoPdb)
ONC201 was later reported as an allosteric activator of the oncology drug target, mitochondrial protease caseinolytic protease P (ClpP) . It also antagonises dopamine D2/3 receptor signalling . (GtoPdb)
PRICE
56
DESCRIPTION
ONC201 is an activator of ATP-dependent Clp protease proteolytic subunit 1 with EC50 = 820 nM
(Enamine Bioactive Compounds)
DESCRIPTION
TIC10 (ONC-201) inactivates Akt and ERK to induce TRAIL through Foxo3a, possesses superior drug properties: delivery across the blood-brain barrier, superior stability and improved pharmacokinetics. Phase 1/2.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
33
Organisms
0
Compound Sets
15
AdooQ Bioactive Compound Library
Axon Medchem Screening Library
Cayman Chemical Bioactives
ChEMBL Drugs
Drug Repurposing Hub
DrugBank
DrugMAP
Enamine Bioactive Compounds
Guide to Pharmacology
Mcule NIBR MoA Box Subset
Novartis Chemogenetic Library (NIBR MoA Box)
Obsolete Compounds
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
28
Molecular Weight
386.21
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
0
Rotatable Bonds
4
Ring Count
5
Aromatic Ring Count
2
cLogP
3.17
TPSA
39.15
Fraction CSP3
0.33
Chiral centers
0.0
Largest ring
6.0
QED
0.81
Structural alerts
1
historic compounds (Chemical Probes.org)
Obsolete
Related compounds
Custom attributes
(extracted from source data)
Target
Apoptosis
TNF Receptor
Akt
TNFSF10
TRAIL activator
Akt,Apoptosis related,ERK,TNF-alpha
MOA
AKT
ERK
TIC10 inactivates Akt and ERK and induces TRAIL expression
AKT inhibitor, MAP kinase inhibitor
Member status
virtual
Pathway
Cytoskeletal Signaling
PI3K/Akt/mTOR signaling
Source data
