General
Preferred name
PSN632408
Synonyms
P&D ID
PD012406
CAS
857652-30-3
Tags
available
drug candidate
Drug indication
Discovery agent
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION PSN632408, a selective, orally active GPR119 agonist, shows similar potency to OEA at both recombinant mouse and human GPR119 receptors (EC50=5.6 and 7.9 uM, respectively). PSN632408 can stimulate ¦Â-cell replication and improve islet graft function. PSN632408 has the potential for the research of obesity and related metabolic disorders[1][2].
DESCRIPTION PSN632408 is an agonist of glucose-dependent insulinotropic receptor. (Enamine Bioactive Compounds)
DESCRIPTION PSN632408 is an optimized agonist of GPR119 receptors that shows similar potency to OEA at both recombinant mouse and human GPR119 receptors. It suppresses food intake, reduces weight gain, and white adipose tissue deposition in rats. It may be useful as a therapeutic agent for the treatment of obesity. (BOC Sciences Bioactive Compounds)
Compound Sets
10
BOC Sciences Bioactive Compounds
psn632408-cas-857652-30-3-item-84-463656
Cayman Chemical Bioactives
10008594
Concise Guide to Pharmacology 2017/18
3319
Concise Guide to Pharmacology 2019/20
3319
Concise Guide to Pharmacology 2021/22
3319
Concise Guide to Pharmacology 2023/24
3319
DrugMAP
DMJIB8N
Enamine Bioactive Compounds
EBC-07741
Guide to Pharmacology
3319
MedChem Express Bioactive Compound Library
HY-16673
External IDs
17
Properties
(calculated by RDKit )
Molecular Weight
360.18
Hydrogen Bond Acceptors
7
Hydrogen Bond Donors
0
Rotatable Bonds
4
Ring Count
3
Aromatic Ring Count
2
cLogP
3.05
TPSA
90.58
Fraction CSP3
0.56
Chiral centers
0.0
Largest ring
6.0
QED
0.83
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Target
GPR119
Pathway
GPCR/G protein
Neuronal Signaling
Source data