General
Preferred name
SN 2
Synonyms
SN-2 ()
P&D ID
PD012404
CAS
823218-99-1
Tags
available
drug candidate
Drug indication
Discovery agent
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Selective TRPML3 channel activator
(Tocriscreen Plus)
DESCRIPTION
Potent and selective NaV1.8 channel blocker; active in vivo
(Tocris Bioactive Compound Library)
DESCRIPTION
SN 2 is a novel and potent small molecule activator of TRPML3. Its EC50 value is 1.13 uM. It had a similar synergistic effect and reached up-to 10-fold enhancement of the combined response when compared with the individual responses.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
6
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
9
Molecular Weight
255.16
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
0
Rotatable Bonds
1
Ring Count
4
Aromatic Ring Count
1
cLogP
3.76
TPSA
21.59
Fraction CSP3
0.59
Chiral centers
4.0
Largest ring
6.0
QED
0.75
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
Ion Channels
Primary Target
TRPML
MOA
Activator
Pathway
Anti-infection
Membrane Transporter/Ion Channel
Neuronal Signaling
Target
Dengue virus
Flavivirus
TRP Channel
Solubility
DMSO: ≥ 23.5 mg/mL
Source data
