General
Preferred name
ARBACLOFEN
Synonyms
(R)-Baclofen (hydrochloride) ()
STX 209 hydrochloride ()
STX209 ()
(R)-Baclofen ()
[3H](R)-(-)-baclofen ()
STX 209 ()
[3H](R)-(-)-baclofen ()
Arbaclofene ()
Baclofen, r(-)- ()
Baclofen, (r)- ()
STX-209 ()
Arbaclofeno ()
Baclofen, r- ()
D-baclofen ()
Baclofen (r)-form ()
R-(-)-baclofen ()
(+)-Baclofen (hydrochloride) ()
P&D ID
PD012374
CAS
69308-37-8
63701-55-3
Tags
available
drug candidate
Drug indication
Multiple sclerosis
Drug Status
investigational
Max Phase
3.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Specific group III mGlu antagonist (Tocris Bioactive Compound Library)
Cell lines
0
Organisms
2
Compound Sets
21
Cayman Chemical Bioactives
31595
ChEMBL Drugs
CHEMBL301742
Concise Guide to Pharmacology 2017/18
1064
3428
Concise Guide to Pharmacology 2019/20
1064
3428
Concise Guide to Pharmacology 2021/22
1064
3428
Concise Guide to Pharmacology 2023/24
1064
3428
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DB08891
DrugMAP
DMLRHM5
EU-OPENSCREEN Bioactive Compound Library
EOS100733
Guide to Pharmacology
1064
3428
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL301742
Mcule NIBR MoA Box Subset
MCULE-2275748923
MedChem Express Bioactive Compound Library
HY-17354
Novartis Chemogenetic Library (NIBR MoA Box)
ReFrame library
Selleckchem Bioactive Compound Library
r-baclofen
TargetMol Bioactive Compound Library
T6355
Tocris Bioactive Compound Library
0796
ZINC Tool Compounds
ZINC000000000061
External IDs
51
Properties
(calculated by RDKit )
Molecular Weight
213.06
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
2
Rotatable Bonds
4
Ring Count
1
Aromatic Ring Count
1
cLogP
1.86
TPSA
63.32
Fraction CSP3
0.3
Chiral centers
1.0
Largest ring
6.0
QED
0.8
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
GABA Receptor
GABAR
GABBR1, GABBR2
Pathway
Neuronal Signaling
Membrane Transporter/Ion Channel
Neuroscience
Primary Target
GABAB Receptors
MOA
GABA Receptor agonist
Agonist
GABA(B) Agonists
benzodiazepine receptor agonist
Member status
member
Source data