General
Preferred name
NORTADALAFIL
Synonyms
Demethyl Tadalafil ()
Nortadalafil ()
P&D ID
PD012339
CAS
171596-36-4
Tags
available
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Nortadalafil (Demethyl Tadalafil), a tadalafil (HY-90009A) analogue detected in health foods, is a highly selective PDE5 inhibitor. Nortadalafil is used in the research of erectile dysfunction (ED). Nortadalafil can be formed by closing the diketopiperazine ring in high yield. Nortadalafil is promising for research of pulmonary arterial hypertension[1][2][3][4][5][6].
PRICE 92
DESCRIPTION Nortadalafil is a N-desmethyl analogue of the human PDE5 inhibitor Tadalafil. It is a potential antiplasmodial drug. It has inhibitory activityagainst human recombinant phosphodiesterase type 5 (PDE5), IC50 = 2nM. (Enamine Bioactive Compounds)
DESCRIPTION Nortadalafil (Demethyl Tadalafil) is demethyl Tadalafil, which is a PDE5 inhibitor, treating erectile dysfunction (ED) ; and under the name Adcirca for the treatment of pulmonary arterial hypertensio. (TargetMol Bioactive Compound Library)
Cell lines
0
Organisms
1
Compound Sets
3
Enamine Bioactive Compounds
EBC-44165
MedChem Express Bioactive Compound Library
HY-90009
TargetMol Bioactive Compound Library
T6147
External IDs
19
Properties
(calculated by RDKit )
Molecular Weight
375.12
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
2
Rotatable Bonds
1
Ring Count
6
Aromatic Ring Count
3
cLogP
1.87
TPSA
83.66
Fraction CSP3
0.24
Chiral centers
2.0
Largest ring
6.0
QED
0.68
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
PDE5
phosphodiesterase
Phosphodiesterase (PDE)
Pathway
Metabolism
Metabolic Enzyme/Protease
Source data