General
Preferred name
ESTRADIOL CYPIONATE
Synonyms
Lunelle-estradiol cypionate ()
Estradiol cypionate component of lunelle ()
Estradiol cipionate ()
Estradiol 17.beta.-cyclopentanepropanoate ()
NSC-3354 ()
Depo-Estradiol ()
Depo ()
Estradiol cypionate component of depo-testadiol ()
P&D ID
PD012309
CAS
313-06-4
Tags
available
drug
prodrug
Approved by
FDA
First approval
1979
Drug indication
Hormone replacement therapy
Drug Status
approved
investigational
vet_approved
Max Phase
4.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
MOA
Estradiol enters target cells freely (e.g., female organs, breasts, hypothalamus, pituitary) and interacts with a target cell receptor. When the estrogen receptor has bound its ligand it can enter the nucleus of the target cell, and regulate gene transcription which leads to formation of messenger RNA. The mRNA interacts with ribosomes to produce specific proteins that express the effect of estradiol upon the target cell. Estrogens increase the hepatic synthesis of sex hormone binding globulin (SHBG), thyroid-binding globulin (TBG), and other serum proteins and suppress follicle-stimulating hormone (FSH) from the anterior pituitary.; ; Increases in the down-stream effects of ER binding reverses some of the symptoms of menopause and of hypoestrogenism, which are primarily caused by a loss of estrogenic activity.
DESCRIPTION
Estradiol cypionate is the 17¦Â-cypionate ester of Estradiol, which inhibits ET-1 synthesis by acting on estrogen receptors[1].
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
15
Cayman Chemical Bioactives
ChEMBL Approved Drugs
ChEMBL Drugs
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
MedChem Express Bioactive Compound Library
Natural product-based probes and drugs
NPC Screening Collection
ReFrame library
Selleckchem Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
27
Molecular Weight
396.27
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
1
Rotatable Bonds
4
Ring Count
5
Aromatic Ring Count
1
cLogP
6.13
TPSA
46.53
Fraction CSP3
0.73
Chiral centers
5.0
Largest ring
6.0
QED
0.62
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Indication
hypoestrogenism, menopause
Target
ESR1
Apoptosis
Estrogen Receptor/ERR
Estrogen/progestogen Receptor
MOA
Estrogen receptor agonist
Biosynthetic Origin
Terpenoid (Steroid)
Therapeutic Indication
Contraception
Therapeutic Class
Hormone Therapy
Pathway
Vitamin D Related/Nuclear Receptor
Source data
