General
Preferred name
acarbose
Synonyms
Acarbose (sulfate) ()
Bay-g 5421 sulfate ()
BAY g 5421,Prandase, Precose, Glucobay, Bay-g 5421 ()
BAY g 5421 ()
Precose ()
BAY-G-5421 ()
Glucobay ()
NSC-758915 ()
P&D ID
PD012297
CAS
56180-94-0
Tags
covalent binder
natural product
drug
available
Drug Status
approved
Max Phase
Phase 4
Drug indication
Inhibitor (alpha-glucosidase)
First approval
1995
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Maltase-glucoamylase and pancreatic amylase inhibitor. Many isomeric alternative structures for this compound are available: to go to the PubChem listing click here. It is not clear which isomer is an exact match to the structure given in the INN record for this compound.
(GtoPdb)
DESCRIPTION
Glucosidase alpha inhibitor (intestinal)
(Tocriscreen Plus)
DESCRIPTION
Inhibitor of gamma-secretase-mediated betaAPP processing
(Tocris Bioactive Compound Library)
DESCRIPTION
Glucosidase α inhibitor (intestinal)
(Tocriscreen Total)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
15
AdooQ Bioactive Compound Library
CeMM library of unique drugs (CLOUD)
ChEMBL Approved Drugs
ChEMBL Drugs
Drug Repurposing Hub
Guide to Pharmacology
LSP-MoA library (Laboratory of Systems Pharmacology)
Other bioactive compounds
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
Tocris Bioactive Compound Library
Tocriscreen Plus
Tocriscreen Total
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
34
Molecular Weight
645.25
Hydrogen Bond Acceptors
19
Hydrogen Bond Donors
14
Rotatable Bonds
9
Ring Count
4
Aromatic Ring Count
0
cLogP
-8.56
TPSA
321.17
Fraction CSP3
0.92
Chiral centers
19.0
Largest ring
6.0
QED
0.1
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
Enzymes
MOA
alpha glucosidase inhibitor
Inhibitor
glucosidase inhibitor
Target
Maltase-glucoamylase
Pancreatic alpha-amylase
AMY2A, MGAM
Carbohydrate Metabolism
Primary Target
Glycosylases
Indication
diabetes mellitus
Source data
